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The Protective Activity of Linear Furanocoumarins from Angelica dahurica against Glucose-mediated Protein Damage
- Authors
- Kim, Hyun Young; Lee, Ki Ho; Lee, Dong Gu; Lee, Sanghyun
- Issue Date
- Jun-2012
- Publisher
- KOREAN SOC APPLIED BIOLOGICAL CHEMISTRY
- Keywords
- advanced glycation end products; Angelica dahurica; coumarin; diabetes mellitus; Umbelliferae
- Citation
- JOURNAL OF THE KOREAN SOCIETY FOR APPLIED BIOLOGICAL CHEMISTRY, v.55, no.3, pp 355 - 358
- Pages
- 4
- Indexed
- SCIE
SCOPUS
KCI
- Journal Title
- JOURNAL OF THE KOREAN SOCIETY FOR APPLIED BIOLOGICAL CHEMISTRY
- Volume
- 55
- Number
- 3
- Start Page
- 355
- End Page
- 358
- ISSN
- 1738-2203
2234-344X
- Abstract
- Advanced glycation end products (AGEs) are known to be directly involved in diabetes mellitus and aging. Therefore, protective activities of isoimperatorin, imperatorin, byakangelicin, and oxypeucedanin hydrate from Angelica dahurica on the formation of AGEs were examined using an in vitro glycation reaction. Isoimperatorin showed strong inhibitory activity against the formation of AGEs. The inhibitory activity of isoimperatorin was more potent than that of the positive control, aminoguanidine. These results suggest that isoimperatorin from A. dahurica may be a promising agent for the treatment of glycation-associated diseases.
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