Validating the Health Benefits of Coffee Berry Pulp Extracts in Mice with High-Fat Diet-Induced Obesity and Diabetesopen access
- Authors
- Bashir, Khawaja Muhammad Imran; Kim, Joo Wan; Park, Hye-Rim; Lee, Jae-Kyoung; Choi, Beom-Rak; Choi, Jae-Suk; Ku, Sae-Kwang
- Issue Date
- Jan-2024
- Publisher
- Multidisciplinary Digital Publishing Institute (MDPI)
- Keywords
- antioxidant; Coffea arabicaL; coffee berry pulp; diabetic obese mice; high-fat-diet; type 2 diabetes
- Citation
- Antioxidants, v.13, no.1
- Indexed
- SCIE
SCOPUS
- Journal Title
- Antioxidants
- Volume
- 13
- Number
- 1
- URI
- https://scholarworks.gnu.ac.kr/handle/sw.gnu/69632
- DOI
- 10.3390/antiox13010010
- ISSN
- 2076-3921
2076-3921
- Abstract
- The effects of coffee (Coffea arabica L.) berry pulp extracts (CBP extracts) on the improvement of diabetes, obesity, and non-alcoholic fatty liver disease (NAFLD) were evaluated using various in vitro antioxidant activity assays and through a high-fat diet-induced mild diabetic obese mouse model. After an 84-day oral administration of CBP extracts (400–100 mg/kg), bioactivities were evaluated. The in vitro analysis showed the highest DPPH● scavenging activity of 73.10 ± 4.27%, ABTS● scavenging activity of 41.18 ± 1.14%, and SOD activity of 56.24 ± 2.81%, at a CBP extract concentration of 1000 µg/mL. The in vivo analysis of the CBP extracts showed favorable and dose-dependent anti-obesity, anti-diabetic, NAFLD, nephropathy, and hyperlipidemia refinement effects through hepatic glucose enzyme activity, 5′-AMP-activated protein kinase (AMPK) up-regulation, antioxidant activity, lipid metabolism-related gene expression, and pancreatic lipid digestion enzyme modulatory activities. This study shows that an appropriate oral dosage of CBP extracts could function as a potent herbal formulation for a refinement agent or medicinal food ingredient to control type 2 diabetes and related complications. © 2023 by the authors.
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