홍화씨와 흰민들레 복합물의 Scopolamine 유도 기억력 손상에 대한 보호 효과Protective Effects of Combination of Carthamus tinctorius L. Seed and Taraxacum coreanum on Scopolamine-induced Memory Impairment in Mice
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- Protective Effects of Combination of Carthamus tinctorius L. Seed and Taraxacum coreanum on Scopolamine-induced Memory Impairment in Mice
- 김지현; 조은주; 박찬흠; 신유수; Mei Tong He; 김민조; 이재양
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- 한국약용작물학회지, v.28, no.2, pp.85 - 94
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- Background: Alzheimer’s disease (AD) is caused by various factors, such as cholinergic dysfunction, regulation of neurotrophic factor expression, and accumulation of amyloid-beta. We investigated whether or not a combination of Carthamus tinctorius L. seed and Taraxacum coreanum (CT) has a protective effect on scopolamine-induced memory impairment in a mouse model. Methods and Results: Mice were orally pretreated with CT (50, 100 and 200 ㎎/㎏/day) for 14 days, and scopolamine (1 ㎎/㎏/day) was injected intraperitoneally before subjecting them to behavior tests. CT-administered mice showed better novel object recognition and working memory ability than scopolamine-treated control mice. In T-maze and Morris water maze tests, CT (100 and 200 ㎎/㎏/day) significantly increased space perceptive ability and occupancy to the target quadrant, respectively. In addition, 100 and 200 ㎎/㎏/day of CT attenuated cholinergic dysfunction through inhibition of butyryl cholinesterase in brain tissue. Furthermore, CT-administered mice showed higher cyclic adenosine monophosphate-response element-binding protein (CREB) levels and lower amyloid precursor protein (APP) levels compared to scopolamine-treated control mice. Conclusions: CT improved scopolamine-induced memory impairment through inhibition of cholinergic dysfunction, up-regulation of CREB, and down-regulation of APP. Therefore, CT could be a useful therapeutic agent for AD with protective effects on cognitive impairment.
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- 자연과학대학 > 식품영양학과 > Journal Articles
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