Protective effects of Carthamus tinctorius L. Seed on C6 glial cells treated with ethanolopen access
- Choi, S.H.; Park, C.H.; Cho, E.J.; Kim, J.H.; Seo, W.T.
- Issue Date
- Korean Society for Applied Biological Chemistry
- Antioxidant; Carthamus tinctorius L. seed; Ethanol; Glial cells; Reactive oxygen species
- Journal of Applied Biological Chemistry, v.64, no.1, pp.69 - 74
- Journal Title
- Journal of Applied Biological Chemistry
- Start Page
- End Page
- Chronic alcohol is responsible for oxidative stress and neurodegenerative diseases such as dementia. In the present study, we investigated the antioxidant activity and protective effects of seed of Carthamus tinctorius L. on ethanol-induced C6 glial cells. Antioxidant effect of seed of C. tinctorius L. was measured by scavenging activity of 1,1-diphenyl-2-prcrylhydrazy (DPPH), hydroxyl radical (·OH), superoxide radical, and nitric oxide. The seed of C. tinctorius L. extract showed significant radical scavenging activities in a concentration-dependent manner. In particular, it revealed strong DPPH and ·OH scavenging activity, displaying more than 80% at 500 and 100 μg/mL, respectively. Treatment of 500 mM ethanol to C6 glial cell led to decline of cell viability and elevation of reactive oxygen species (ROS) generation. However, seed of C. tinctorius L.-treated groups significantly increased cell viability and decreased ROS levels, compared to ethanol-induced control group. These results suggest that seed of C. tinctorius L. would have protective effect against neuronal oxidative stress induced by alcohol. ? 2021, Korean Society for Applied Biological Chemistry. All rights reserved.
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- 농업생명과학대학 > 식품공학부 > Journal Articles
- 자연과학대학 > 식품영양학과 > Journal Articles
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