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Protective effect of ginseng sapogenins against 2,2 '-azobis (1-aminopropane) dihydrochloride (AAPH)-induced LLC-PK1 cell damage
- Authors
- Kang, Ki Sung; Kim, Hyun Young; Yoo, Hye Hyun; Piao, Xiang Lan; Ham, Jungyeob; Yang, Hyun Ok; Park, Jeong Hill
- Issue Date
- 1-Jan-2012
- Publisher
- PERGAMON-ELSEVIER SCIENCE LTD
- Keywords
- Panax ginseng; Renoprotective activity; Ginsenoside; Sapogenin
- Citation
- BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, v.22, no.1, pp 634 - 637
- Pages
- 4
- Indexed
- SCI
SCIE
SCOPUS
- Journal Title
- BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Volume
- 22
- Number
- 1
- Start Page
- 634
- End Page
- 637
- ISSN
- 0960-894X
1464-3405
- Abstract
- The effect of ginseng sapogenins, aglycone parts of ginsenosides, against oxidative damage by radical generator, 2,2'-azobis (2-amidinopropane) dihydrochloride (AAPH), in renal epithelial LLC-PK1 cells was investigated to identify the structural characteristics of sapogenins to have renoprotective effects. Of the tested sapogenins, Delta(20(21))-protopanaxatriol showed the strongest protective effect against the AAPH-induced LLC-PK1 cell damage. Based on the structure and stronger activity of Delta(20(21))-protopanaxatriol than the other sapogenins, the hydroxyl group in C-6 and double bond in C-20(21) position were important for renoprotective effect of sapogenin against oxidative stress. (C) 2011 Elsevier Ltd. All rights reserved.
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