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Effect of the licorice flavonoid isoliquiritigenin on the sleep architecture and profile in mice
- Authors
- Cho, Suengmok; Yoon, Minseok; Kim, Dongsoo; Kim, Jin-Soo; Yang, Heyjin; Lee, Chang-Ho; Kim, In-Ho; Shimizu, Makoto; Han, Daeseok
- Issue Date
- Aug-2012
- Publisher
- KOREAN SOCIETY FOOD SCIENCE & TECHNOLOGY-KOSFOST
- Keywords
- isoliquiritigenin; sleep-promoting effect; sleep architecture; electroencephalogram; electromyogram
- Citation
- FOOD SCIENCE AND BIOTECHNOLOGY, v.21, no.4, pp.1221 - 1225
- Indexed
- SCIE
SCOPUS
KCI
- Journal Title
- FOOD SCIENCE AND BIOTECHNOLOGY
- Volume
- 21
- Number
- 4
- Start Page
- 1221
- End Page
- 1225
- ISSN
- 1226-7708
- Abstract
- The sleep-promoting effect of isoliquiritigenin (ILTG) was investigated by analyzing the sleep architecture in mice. A hypnotic diazepam (DZP, 2 mg/kg) significantly decreased sleep latency by 39.7% and increased the amount of non-rapid eye movement sleep (NREMS) by 103.8% for the first 3 h after administration. ILTG (50 mg/kg) also produced a significant decrease in sleep latency (30.7%) and an increase in the amount of NREMS (61.1%). DZP significantly decreased delta (0.5-4 Hz) activity as compared with the vehicle; however, ILTG did not alter the delta activity. These results mean that ILTG induces sleep similar to physiological sleep without a decline in sleep quality.
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