Detailed Information

Cited 33 time in webofscience Cited 0 time in scopus
Metadata Downloads

T1 mapping for liver function evaluation in gadoxetic acid-enhanced MR imaging: comparison of look-locker inversion recovery and B-1 inhomogeneity-corrected variable flip angle method

Authors
Kim, Ji EunKim, Hyun OkBae, KyungsooChoi, Dae SeobNickel, Dominik
Issue Date
Jul-2019
Publisher
SPRINGER
Keywords
Liver; Magnetic resonance imaging; Gadoxetic acid; Cirrhosis
Citation
EUROPEAN RADIOLOGY, v.29, no.7, pp.3584 - 3594
Indexed
SCIE
SCOPUS
Journal Title
EUROPEAN RADIOLOGY
Volume
29
Number
7
Start Page
3584
End Page
3594
URI
https://scholarworks.bwise.kr/gnu/handle/sw.gnu/8988
DOI
10.1007/s00330-018-5947-4
ISSN
0938-7994
Abstract
ObjectivesTo compare look-locker inversion recovery (LLIR) and B-1 inhomogeneity-corrected variable flip angle T1 mapping methods for estimation of liver function and prediction of hepatic insufficiency and decompensation on gadoxetic acid-enhanced MR imaging.MethodsIn this retrospective study, 248 patients with normal liver function, chronic liver disease, or cirrhosis underwent gadoxetic acid-enhanced liver MR imaging, including T1 mapping at 10-min and 20-min hepatobiliary phase (HBP) by using both methods. T1 relaxation times of the liver (T1(Liver-pre), T1(Liver-post)) and the spleen (T1(Spleen)) were correlated between two methods. T1(Liver) ([T1(Liver-pre) - T1(Liver-post)]/T1(Liver-pre)), adjusted T1(Liver) ([T1(Spleen) - T1(Liver-post)]/T1(Spleen)), and functional liver volume-to-weight ratio (liver volume on volumetric T1 map/[T1(Liver-post) x patient's weight]) were calculated. The diagnostic performance of T1 parameters and the predictive performance of models (serum marker, serum marker plus T1 parameter) were compared.ResultsT1(Liver-post) showed a strong correlation (r=0.93, p<0.001) between two methods but was significantly different. For depicting cirrhosis, LLIR-adjusted T1(Liver) at 10-min HBP showed the highest performance (p<0.025). For predicting hepatic insufficiency and decompensation, LLIR-adjusted T1(Liver) (Akaike information criterion (AIC), 58.37; C-index, 0.867) and LLIR-T1(Liver-post) (AIC, 48.82; C-index, 0.885) at 10-min HBP showed the best performance, respectively, when added to serum albumin level.ConclusionsT1(Liver-post) showed a strong correlation between two methods but with significant differences. T1 mapping using LLIR at 10-min HBP with obtainment of adjusted T1(Liver) and T1(Liver-post) may be the best approach for estimation of liver function and prediction of hepatic insufficiency and decompensation.Key Points center dot T1(Liver-post)showed a strong correlation between LLIR and B(1)inhomogeneity-corrected VFA methods, both at 10-min and 20-min HBP but with significant differences.center dot T1(Liver-post)at 10-min and 20-min HBP using LLIR and B(1)inhomogeneity-corrected VFA methods could not be used interchangeably during the follow-up in patients with chronic liver disease (CLD) or cirrhosis.center dot T1 mapping using LLIR at 10-min HBP with obtainment of adjusted T1(Liver)and T1(Liver-post)may be the most suitable method and parameter for estimation of global liver function and prediction of clinical outcomes in patients with CLD or cirrhosis.
Files in This Item
There are no files associated with this item.
Appears in
Collections
College of Medicine > Department of Medicine > Journal Articles

qrcode

Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.

Related Researcher

Researcher Choi, Dae Seob photo

Choi, Dae Seob
의과대학 (의학과)
Read more

Altmetrics

Total Views & Downloads

BROWSE