참풀가사리(Gloiopeltis tenax) 추출물의 항산화성 및 항치매활성

Abstract

In this study, we investigated the antioxidant and anti-dementia activities of the Korean marine algae Gloiopeltis tenax. Solvent extracts were prepared using 70% ethanol, 80% methanol, and distilled water. The extraction yields from the different solvents ranged from 8.52% to 49.47%. The total polyphenol and flavonoid contents ranged from 9.13–15.80 mg/g and 0.42–3.33 mg/g, respectively. The ethanol extract showed the highest 2,2′-azino-bis(3-ethylbenzothiazoline- 6-sulfonic acid) radical scavenging activity, whereas the methanol extract exhibited the strongest reducing power and ferric reducing antioxidant power. Additionally, both the ethanol and methanol extracts exhibited higher acetylcholinesterase inhibitory activities (IC50=0.89–0.95 mg/mL) than that of the water extract. In contrast, the water extract exhibited the highest β-secretase inhibitory activity (IC50=17.03 μg/mL). These results indicate that G. tenax may be useful as an antioxidant and functional ingredient for food and pharmaceuticals, particularly for its anti-dementia properties.