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N121T and N121S substitutions on the SARS-CoV-2 spike protein impact on serum neutralization
- Authors
- Lo, Van Thi; Lim, Hyun A.; Jang, Seong Sik; Kim, Min Chan; Chamfort, Alain Chrysler; Kim, Ha Yeon; Mun, Da Young; Kang, Min Chang; Lee, Han Byul; Kim, Sunjoo; Lee, Younghee; Park, Sangkyu; Yoon, Sun-Woo; Kim, Hye Kwon
- Issue Date
- Sep-2024
- Publisher
- John Wiley & Sons Inc.
- Keywords
- biliverdin; N121S; N121T; neutralizing; NTD; SARS-CoV-2
- Citation
- Journal of Medical Virology, v.96, no.9
- Indexed
- SCIE
SCOPUS
- Journal Title
- Journal of Medical Virology
- Volume
- 96
- Number
- 9
- ISSN
- 0146-6615
1096-9071
- Abstract
- The N121 site on the spike protein of SARS-CoV-2 is associated with heme and its metabolite, biliverdin, which can affect antibody binding. Both N121T and N121S substitutions have been observed in natural conditions and in a hamster model of dual infection with SARS-CoV-2 and Influenza A virus. Serum pseudotype neutralization assays against HIV-1 particles carrying wild-type, N121T, and N121S spikes with immune mouse and human sera revealed that N121T and N121S mutations had a greater impact on serum neutralization than biliverdin treatment. Although N121T and N121S substitutions are not currently major SARS-CoV-2 variants of concern, this study could provide fundamental information to prepare for potential future mutations at the N121 site of SARS-CoV-2. © 2024 Wiley Periodicals LLC.
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