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N121T and N121S substitutions on the SARS-CoV-2 spike protein impact on serum neutralization

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dc.contributor.authorLo, Van Thi-
dc.contributor.authorLim, Hyun A.-
dc.contributor.authorJang, Seong Sik-
dc.contributor.authorKim, Min Chan-
dc.contributor.authorChamfort, Alain Chrysler-
dc.contributor.authorKim, Ha Yeon-
dc.contributor.authorMun, Da Young-
dc.contributor.authorKang, Min Chang-
dc.contributor.authorLee, Han Byul-
dc.contributor.authorKim, Sunjoo-
dc.contributor.authorLee, Younghee-
dc.contributor.authorPark, Sangkyu-
dc.contributor.authorYoon, Sun-Woo-
dc.contributor.authorKim, Hye Kwon-
dc.date.accessioned2024-12-03T05:30:41Z-
dc.date.available2024-12-03T05:30:41Z-
dc.date.issued2024-09-
dc.identifier.issn0146-6615-
dc.identifier.issn1096-9071-
dc.identifier.urihttps://scholarworks.gnu.ac.kr/handle/sw.gnu/74341-
dc.description.abstractThe N121 site on the spike protein of SARS-CoV-2 is associated with heme and its metabolite, biliverdin, which can affect antibody binding. Both N121T and N121S substitutions have been observed in natural conditions and in a hamster model of dual infection with SARS-CoV-2 and Influenza A virus. Serum pseudotype neutralization assays against HIV-1 particles carrying wild-type, N121T, and N121S spikes with immune mouse and human sera revealed that N121T and N121S mutations had a greater impact on serum neutralization than biliverdin treatment. Although N121T and N121S substitutions are not currently major SARS-CoV-2 variants of concern, this study could provide fundamental information to prepare for potential future mutations at the N121 site of SARS-CoV-2. © 2024 Wiley Periodicals LLC.-
dc.language영어-
dc.language.isoENG-
dc.publisherJohn Wiley & Sons Inc.-
dc.titleN121T and N121S substitutions on the SARS-CoV-2 spike protein impact on serum neutralization-
dc.typeArticle-
dc.publisher.location미국-
dc.identifier.doi10.1002/jmv.29871-
dc.identifier.scopusid2-s2.0-85202997480-
dc.identifier.wosid001321738800030-
dc.identifier.bibliographicCitationJournal of Medical Virology, v.96, no.9-
dc.citation.titleJournal of Medical Virology-
dc.citation.volume96-
dc.citation.number9-
dc.type.docTypeArticle-
dc.description.isOpenAccessN-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.relation.journalResearchAreaVirology-
dc.relation.journalWebOfScienceCategoryVirology-
dc.subject.keywordAuthorbiliverdin-
dc.subject.keywordAuthorN121S-
dc.subject.keywordAuthorN121T-
dc.subject.keywordAuthorneutralizing-
dc.subject.keywordAuthorNTD-
dc.subject.keywordAuthorSARS-CoV-2-
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