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Changes in Macular Thickness and Microvasculature in Koreans with Early Parkinson’s Disease; [한국인 초기 파킨슨 환자에서 황반두께 및 미세혈관 변화]open access

Authors
Kwon, Lee HaCho, Yong WunKim, Seong-JaeChung, InyoungYoo, Woong Sun
Issue Date
Nov-2023
Publisher
Korean Ophthalmological Society (KOS)
Keywords
Neurodegeneration; Optical coherence tomography; Optical coherence tomography angiography; Parkinson’s disease
Citation
Journal of Korean Ophthalmological Society, v.64, no.11, pp 1055 - 1062
Pages
8
Indexed
SCOPUS
ESCI
KCI
Journal Title
Journal of Korean Ophthalmological Society
Volume
64
Number
11
Start Page
1055
End Page
1062
URI
https://scholarworks.gnu.ac.kr/handle/sw.gnu/68829
DOI
10.3341/jkos.2023.64.11.1055
ISSN
0378-6471
2092-9374
Abstract
Рurроsе: To investigate the thickness of the nerve fiber layer-ganglion cell inner plexiform layer (NFL-GCIPL) complex and microvascular macular changes in Korean patients with early Parkinson’s disease using optical coherence tomography (OCT) and OCT angiography (OCTA). Меthоds: Forty-three eyes of 22 patients with early Parkinson’s disease were included. A control group of 20 patients (40 eyes) was also recruited. The thickness of the NFL-GCIPL macular complex was measured using OCT, and the densities of the superficial and deep macular retinal vessels were evaluated via OCTA in all subjects. Rеsults: The NFL-GCIPL thicknesses of the superior, inferior, temporal, and nasal sectors were 94.70 ± 9.35, 93.32 ± 9.16, 90.18 ± 6.32, and 93.11 ± 8.75 μm in the control group and 92.05 ± 4.96, 91.32 ± 7.48, 84.74 ± 6.82, and 91.32 ± 7.47 μm in the Parkinson’s disease group, respectively; all thicknesses were significantly greater in the control group. The superficial and deep retinal vessel densities did not differ between the two groups. Cоnсlusіоns: Neurodegenerative macular changes are more obvious than microvascular changes in patients with early Parkinson’s disease. Such neurodegenerative changes should be further evaluated in future cohort studies. J Korean Ophthalmol Soc 2023;64(11):1055-1062 © 2023 The Korean Ophthalmological Society.
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