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Developing a procedure to extract chenodeoxycholic acid and synthesize ursodeoxycholic acid from pig by-productsopen access

Authors
Kim, On YouLee, Seung YunLee, Da YoungHur, Sun Jin
Issue Date
Jul-2023
Publisher
Elsevier Ltd
Keywords
Bile salt hydrolase enzymes; Chenodeoxycholic acid extraction; Pig by-products; Ursodeoxycholic acid synthesis
Citation
Heliyon, v.9, no.7
Indexed
SCIE
SCOPUS
Journal Title
Heliyon
Volume
9
Number
7
URI
https://scholarworks.gnu.ac.kr/handle/sw.gnu/68743
DOI
10.1016/j.heliyon.2023.e18313
ISSN
2405-8440
2405-8440
Abstract
This study was conducted to develop simple methods for the extraction of chenodeoxycholic acid (CDCA) and synthesis of ursodeoxycholic acid (UDCA) from pig by-products. The enzymatic method, which uses bile salt hydrolase (BSH) enzymes to extract CDCA, was found to be more efficient than the chemical method. The chemical method, which uses pig by-products, resulted in UDCA amounts of 6.05 mg, 0.51 mg, 3.04 mg, and 1.26 mg in 100 g of the liver, stomach, small intestine, and large intestine, respectively. The amounts of UDCA synthesized/100 g through the chemical and enzymatic methods required to extract CDCA were 3.48 g and 2.22 g, respectively. The procedure developed in this study was simplified by three stages compared to the conventional chemical method of extracting CDCA. Moreover, this study provides a technique that improves the utilization of pig by-products. © 2023 The Authors
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