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미세먼지(PM2.5)로 유도된 세포(비강, 폐, 뇌)독성에 대한 청각(Codium fragile)의 보호효과Protective effect of Codium fragile extract on fine dust (PM2.5)-induced toxicity in nasal cavity, lung, and brain cells
- Other Titles
- Protective effect of Codium fragile extract on fine dust (PM2.5)-induced toxicity in nasal cavity, lung, and brain cells
- Authors
- Kim, G.H.; Park, S.K.; Kang, J.Y.; Kim, J.M.; Shin, E.J.; Moon, J.H.; Kim, M.J.; Lee, H.L.; Jeong, H.R.; Heo, H.J.
- Issue Date
- Apr-2021
- Publisher
- 한국식품과학회
- Keywords
- Cell protection; Codium fragile; Fine dust
- Citation
- 한국식품과학회지, v.53, no.2, pp 223 - 229
- Pages
- 7
- Indexed
- SCOPUS
KCI
- Journal Title
- 한국식품과학회지
- Volume
- 53
- Number
- 2
- Start Page
- 223
- End Page
- 229
- ISSN
- 0367-6293
- Abstract
- To evaluate the protective effect of Codium fragile on fine dust (PM2.5)-induced cytotoxicity, we investigated its antioxidant activity and cell protective effect on PM2.5-exposed cells. The 40% ethanolic extract of C. fragile showed the highest total phenolic content, whereas the water extract of C. fragile showed the highest total polysaccharide content. The protective effect of the extracts on PM2.5-induced oxidative damage in nasal cavity (RPMI2650), lung (A549), brain (MC-IXC), hippocampus (HT-22), and microglia (BV-2) cells was evaluated by measuring the intracellular reactive oxygen species (ROS) content and cell viability. The results showed that the 40% ethanolic extract more efficiently inhibited ROS production than the water extract. In contrast, PM2.5-exposed cells treated with the water extract showed higher viability than those treated with the 40% ethanolic extract. ? The Korean Society of Food Science and Technology
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