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Dumulmycin, an Antitubercular Bicyclic Macrolide from a Riverine Sediment-Derived Streptomyces sp.
- Authors
- An, Joon Soo; Shin, Bora; Kim, Tae Ho; Hwang, Sunghoon; Shin, Yern-Hyerk; Cui, Jinsheng; Du, Young Eun; Yi, Jungwoo; Nam, Sang-Jip; Hong, Suckchang; Shin, Jongheon; Jang, Jichan; Yoon, Yeo Joon; Oh, Dong-Chan
- Issue Date
- 7-May-2021
- Publisher
- AMER CHEMICAL SOC
- Citation
- ORGANIC LETTERS, v.23, no.9, pp.3359 - 3363
- Indexed
- SCIE
SCOPUS
- Journal Title
- ORGANIC LETTERS
- Volume
- 23
- Number
- 9
- Start Page
- 3359
- End Page
- 3363
- ISSN
- 1523-7060
- Abstract
- Dumulmycin (1) was isolated from Streptomyces sp. DM28, a bacterial strain from a riverine sediment sample. The structure of 1 was elucidated as a bicyclic macrolide possessing 19-membered and 5-membered rings by spectroscopic analysis. The stereochemistry of 1 was determined by J-based configuration analysis, ROESY NMR data, DP4 calculations, and the modified Mosher's method. Genetic analysis identified a trans-acyltransferase polyketide biosynthetic gene cluster for 1. Dumulmycin exhibited in vitro antitubercular activity (MIC50 = 27.1 mu M).
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