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Cited 20 time in webofscience Cited 24 time in scopus
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Dumulmycin, an Antitubercular Bicyclic Macrolide from a Riverine Sediment-Derived Streptomyces sp.

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dc.contributor.authorAn, Joon Soo-
dc.contributor.authorShin, Bora-
dc.contributor.authorKim, Tae Ho-
dc.contributor.authorHwang, Sunghoon-
dc.contributor.authorShin, Yern-Hyerk-
dc.contributor.authorCui, Jinsheng-
dc.contributor.authorDu, Young Eun-
dc.contributor.authorYi, Jungwoo-
dc.contributor.authorNam, Sang-Jip-
dc.contributor.authorHong, Suckchang-
dc.contributor.authorShin, Jongheon-
dc.contributor.authorJang, Jichan-
dc.contributor.authorYoon, Yeo Joon-
dc.contributor.authorOh, Dong-Chan-
dc.date.accessioned2022-12-26T10:16:23Z-
dc.date.available2022-12-26T10:16:23Z-
dc.date.issued2021-05-07-
dc.identifier.issn1523-7060-
dc.identifier.issn1523-7052-
dc.identifier.urihttps://scholarworks.gnu.ac.kr/handle/sw.gnu/3713-
dc.description.abstractDumulmycin (1) was isolated from Streptomyces sp. DM28, a bacterial strain from a riverine sediment sample. The structure of 1 was elucidated as a bicyclic macrolide possessing 19-membered and 5-membered rings by spectroscopic analysis. The stereochemistry of 1 was determined by J-based configuration analysis, ROESY NMR data, DP4 calculations, and the modified Mosher's method. Genetic analysis identified a trans-acyltransferase polyketide biosynthetic gene cluster for 1. Dumulmycin exhibited in vitro antitubercular activity (MIC50 = 27.1 mu M).-
dc.format.extent5-
dc.language영어-
dc.language.isoENG-
dc.publisherAMER CHEMICAL SOC-
dc.titleDumulmycin, an Antitubercular Bicyclic Macrolide from a Riverine Sediment-Derived Streptomyces sp.-
dc.typeArticle-
dc.publisher.location미국-
dc.identifier.doi10.1021/acs.orglett.1c00847-
dc.identifier.scopusid2-s2.0-85106162085-
dc.identifier.wosid000649477300025-
dc.identifier.bibliographicCitationORGANIC LETTERS, v.23, no.9, pp 3359 - 3363-
dc.citation.titleORGANIC LETTERS-
dc.citation.volume23-
dc.citation.number9-
dc.citation.startPage3359-
dc.citation.endPage3363-
dc.type.docTypeArticle-
dc.description.isOpenAccessN-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.relation.journalResearchAreaChemistry-
dc.relation.journalWebOfScienceCategoryChemistry, Organic-
dc.subject.keywordPlusBIOSYNTHETIC GENE-CLUSTER-
dc.subject.keywordPlusABSOLUTE-CONFIGURATION-
dc.subject.keywordPlusPOLYKETIDE-
dc.subject.keywordPlusSEQUENCE-
dc.subject.keywordPlusNMR-
dc.subject.keywordPlusHITACHIMYCIN-
dc.subject.keywordPlusMECHANISM-
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