Protective effects of krill oil on high fat diet-induced cognitive impairment by regulation of oxidative stress
- Kim, Ji Hyun; Seo, Hyo Jeong; Pang, Qi Qi; Kwon, Yu Ri; Kim, Ji-Hyun; Cho, Eun Ju
- Issue Date
- TAYLOR & FRANCIS LTD
- Cognition; high fat diet; memory; krill oil; oxidative stress
- FREE RADICAL RESEARCH, v.55, no.7, pp.799 - 809
- Journal Title
- FREE RADICAL RESEARCH
- Start Page
- End Page
- Consumption of high fat diet (HFD) increases risk of cognitive impairment and memory deficit by elevation of oxidative stress in the brain. In this study, we investigated the protective effects of krill oil (KO) against HFD-induced cognitive impairment in mice. The mice were fed with HFD for 10 weeks, and then KO was orally administered at doses of 100, 200, or 500 mg/kg/d for 4 weeks. To evaluate the cognitive abilities, we carried out the behavior tests, such as T-maze, novel object recognition test, and Morris water maze test. The HFD-induced cognitive impairment mice showed impairments in both spatial memory and novel object cognitive abilities. However, administration of KO at doses of 100, 200, or 500 mg/kg/d improved spatial memory ability and novel object cognition by increase of the exploration of new route and novel object. In addition, KO-administered group improved learning and memory abilities, showing shorter latency to reach hidden platform compared with control group. Furthermore, levels of reactive oxygen species (ROS), lipid peroxidation, and nitric oxide (NO) were significantly elevated by consumption of HFD, indicating that consumption of HFD induces oxidative stress in the brain. However, administration of KO attenuated oxidative stress by decrease of the ROS levels, lipid peroxidation, and NO. This study suggests that KO improves HFD-induced cognitive impairment by attenuation of oxidative stress in the brain. Therefore, KO may play as a promising agent in treatment and prevention of HFD-induced cognitive impairment.
- Files in This Item
- There are no files associated with this item.
- Appears in
- 자연과학대학 > 식품영양학과 > Journal Articles
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.