Arousal-Inducing Effect of Garcinia cambogia Peel Extract in Pentobarbital-Induced Sleep Test and Electroencephalographic Analysisopen access
- Authors
- Kim, Duhyeon; Kim, Jinsoo; Kim, Seonghui; Yoon, Minseok; Um, Minyoung; Kim, Dongmin; Kwon, Sangoh; Cho, Suengmok
- Issue Date
- Aug-2021
- Publisher
- MDPI
- Keywords
- arousal-inducing effect; caffeine; electroencephalography; Garcinia cambogia; psychoactive agent
- Citation
- NUTRIENTS, v.13, no.8
- Indexed
- SCIE
SCOPUS
- Journal Title
- NUTRIENTS
- Volume
- 13
- Number
- 8
- URI
- https://scholarworks.gnu.ac.kr/handle/sw.gnu/3458
- DOI
- 10.3390/nu13082845
- ISSN
- 2072-6643
2072-6643
- Abstract
- Caffeine, a natural stimulant, is known to be effective for weight loss. On this basis, we screened the arousal-inducing effect of five dietary supplements with a weight loss effect (Garcinia cambogia, Coleus forskohlii, Camellia sinensis L., Irvingia gabonensis, and Malus pumila M.), of which the G. cambogia peel extract (GC) showed a significant arousal-inducing effect in the pentobarbital-induced sleep test in mice. This characteristic of GC was further evaluated by analysis of electroencephalogram and electromyogram in C57L/6N mice, and it was compared to that of the positive control, caffeine. Administration of GC (1500 mg/kg) significantly increased wakefulness and decreased non-rapid eye movement sleep, similar to that of caffeine (25 mg/kg), with GC and caffeine showing a significant increase in wakefulness at 2 and 6 h, respectively. Compared to that of caffeine, the shorter duration of efficacy of GC could be advantageous because of the lower possibility of sleep disturbance. Furthermore, the arousal-inducing effects of GC (1500 mg/kg) and caffeine (25 mg/kg) persisted throughout the chronic (3 weeks) administration study. This study, for the first time, revealed the arousal-inducing effect of GC. Our findings suggest that GC might be a promising natural stimulant with no side effects. In addition, it is preferential to take GC as a dietary supplement for weight loss during the daytime to avoid sleep disturbances owing to its arousal-inducing effect.
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