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Cited 11 time in webofscience Cited 12 time in scopus
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Mixture of Phlorotannin and Fucoidan from Ecklonia cava Prevents the A beta-Induced Cognitive Decline with Mitochondrial and Cholinergic Activationopen access

Authors
Han, Hye JuPark, Seon KyeongKang, Jin YongKim, Jong MinYoo, Seul KiKim, Dae-OkKim, Gun-HeeHeo, Ho Jin
Issue Date
Aug-2021
Publisher
Multidisciplinary Digital Publishing Institute (MDPI)
Keywords
Ecklonia cava; phlorotannin; fucoidan; amyloid-beta; cognition; mitochondrial function; tau phosphorylation; cholinergic function
Citation
Marine Drugs, v.19, no.8
Indexed
SCIE
SCOPUS
Journal Title
Marine Drugs
Volume
19
Number
8
URI
https://scholarworks.gnu.ac.kr/handle/sw.gnu/3446
DOI
10.3390/md19080434
ISSN
1660-3397
Abstract
The anti-amnesic effect of a mixture (4:6 = phlorotannin:fucoidan from Ecklonia cava, P4F6) was evaluated on amyloid-beta peptide (A beta)-induced cognitive deficit mice. The cognitive function was examined by Y-maze, passive avoidance, and Morris water maze tests, and the intake of the mixture (P4F6) showed an ameliorating effect on A beta-induced learning and memory impairment. After the behavioral tests, superoxide dismutase (SOD) activity and thiobarbituric acid-reactive substances (TBARS) contents were confirmed in brain tissue, and in the results, the mixture (P4F6) attenuated A beta-induced oxidative stress. In addition, mitochondrial activity was evaluated by mitochondrial reactive oxygen species (ROS) content, mitochondrial membrane potential (MMP), adenosine triphosphate (ATP) content, and mitochondria-mediated apoptotic signaling pathway, and the mixture (P4F6) enhanced mitochondrial function. Furthermore, the mixture (P4F6) effectively regulated tau hyperphosphorylation by regulating the protein kinase B (Akt) pathway, and promoted brain-derived neurotrophic factor (BDNF) in brain tissue. Moreover, in the cholinergic system, the mixture (P4F6) ameliorated acetylcholine (ACh) content by regulating acetylcholinesterase (AChE) activity and choline acetyltransferase (ChAT) expression in brain tissue. Based on these results, we suggest that this mixture of phlorotannin and fucoidan (P4F6) might be a substance for improving cognitive function by effectively regulating cognition-related molecules.
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