Anti-cancer effects of lucidadiol against malignant melanoma cellsopen access
- Shin, Seong-Ah; Lee, Jun Seob; Joo, Byeong Jun; Ryu, Gyoungah; Han, Minjoo; Kim, Huiji; An, Jangeun; Koo, Man Hyung; Youn, Ui Joung; Lee, Jun Hyuck; Park, Hyun Ho; Lee, Chang Sup
- Issue Date
- SPRINGER SINGAPORE PTE LTD
- Melanoma; Lucidadiol; Anti-cancer; Akt; MAPK
- APPLIED BIOLOGICAL CHEMISTRY, v.64, no.1
- Journal Title
- APPLIED BIOLOGICAL CHEMISTRY
- Melanoma is one of the most aggressive and lethal skin cancers. Lucidadiol is a triterpenoid isolated from Ganoderma lucidum and is known to have various biological functions, including antibacterial effects. However, the anti-cancer effects and mechanism of action of lucidadiol in malignant melanoma are unknown. In this study, lucidadiol significantly reduced B16 melanoma cell viability in a dose- and time-dependent manner. In addition, lucidadiol induced apoptosis and suppressed cell mobility in B16 melanoma cells. Moreover, our findings revealed that lucidadiol remarkably downregulated phospho-Akt/ERK/JNK, but not p38. Taken together, our results suggest that lucidadiol could exerts its anti-cancer effects by inducing apoptosis via modulation of the Akt/MAPK pathway. Therefore, lucidadiol may be a potential cancer therapeutic agent for malignant melanoma.
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- 약학대학 > 약학과 > Journal Articles
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