Anti-cancer effects of lucidadiol against malignant melanoma cells
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Shin, Seong-Ah | - |
dc.contributor.author | Lee, Jun Seob | - |
dc.contributor.author | Joo, Byeong Jun | - |
dc.contributor.author | Ryu, Gyoungah | - |
dc.contributor.author | Han, Minjoo | - |
dc.contributor.author | Kim, Huiji | - |
dc.contributor.author | An, Jangeun | - |
dc.contributor.author | Koo, Man Hyung | - |
dc.contributor.author | Youn, Ui Joung | - |
dc.contributor.author | Lee, Jun Hyuck | - |
dc.contributor.author | Park, Hyun Ho | - |
dc.contributor.author | Lee, Chang Sup | - |
dc.date.accessioned | 2022-12-26T09:45:50Z | - |
dc.date.available | 2022-12-26T09:45:50Z | - |
dc.date.issued | 2021-12 | - |
dc.identifier.issn | 2468-0834 | - |
dc.identifier.issn | 2468-0842 | - |
dc.identifier.uri | https://scholarworks.gnu.ac.kr/handle/sw.gnu/2955 | - |
dc.description.abstract | Melanoma is one of the most aggressive and lethal skin cancers. Lucidadiol is a triterpenoid isolated from Ganoderma lucidum and is known to have various biological functions, including antibacterial effects. However, the anti-cancer effects and mechanism of action of lucidadiol in malignant melanoma are unknown. In this study, lucidadiol significantly reduced B16 melanoma cell viability in a dose- and time-dependent manner. In addition, lucidadiol induced apoptosis and suppressed cell mobility in B16 melanoma cells. Moreover, our findings revealed that lucidadiol remarkably downregulated phospho-Akt/ERK/JNK, but not p38. Taken together, our results suggest that lucidadiol could exerts its anti-cancer effects by inducing apoptosis via modulation of the Akt/MAPK pathway. Therefore, lucidadiol may be a potential cancer therapeutic agent for malignant melanoma. | - |
dc.format.extent | 10 | - |
dc.language | 영어 | - |
dc.language.iso | ENG | - |
dc.publisher | SPRINGER SINGAPORE PTE LTD | - |
dc.title | Anti-cancer effects of lucidadiol against malignant melanoma cells | - |
dc.title.alternative | Anti‑cancer effects of lucidadiol against malignant melanoma cells | - |
dc.type | Article | - |
dc.publisher.location | 싱가폴 | - |
dc.identifier.doi | 10.1186/s13765-021-00647-w | - |
dc.identifier.scopusid | 2-s2.0-85118265897 | - |
dc.identifier.wosid | 000712396200002 | - |
dc.identifier.bibliographicCitation | APPLIED BIOLOGICAL CHEMISTRY, v.64, no.1, pp 1 - 10 | - |
dc.citation.title | APPLIED BIOLOGICAL CHEMISTRY | - |
dc.citation.volume | 64 | - |
dc.citation.number | 1 | - |
dc.citation.startPage | 1 | - |
dc.citation.endPage | 10 | - |
dc.type.docType | Article | - |
dc.identifier.kciid | ART002771192 | - |
dc.description.isOpenAccess | Y | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.description.journalRegisteredClass | kci | - |
dc.relation.journalResearchArea | Food Science & Technology | - |
dc.relation.journalWebOfScienceCategory | Food Science & Technology | - |
dc.subject.keywordPlus | GANODERMA-LUCIDUM | - |
dc.subject.keywordPlus | CYCLE ARREST | - |
dc.subject.keywordPlus | NATURAL COMPOUNDS | - |
dc.subject.keywordPlus | APOPTOSIS | - |
dc.subject.keywordPlus | MIGRATION | - |
dc.subject.keywordPlus | PATHWAY | - |
dc.subject.keywordPlus | MAPK | - |
dc.subject.keywordPlus | P38 | - |
dc.subject.keywordPlus | TRITERPENOIDS | - |
dc.subject.keywordPlus | EPIDEMIOLOGY | - |
dc.subject.keywordAuthor | Melanoma | - |
dc.subject.keywordAuthor | Lucidadiol | - |
dc.subject.keywordAuthor | Anti-cancer | - |
dc.subject.keywordAuthor | Akt | - |
dc.subject.keywordAuthor | MAPK | - |
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