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Inhibitory activity on HIV-1 reverse transcriptase and integrase of a carmalol derivative from a brown alga, Ishige okamurae
- Authors
- Ahn, M.-J.; Yoon, K.-D.; Kim, C.Y.; Kim, J.H.; Shin, C.-G.; Kim, J.
- Issue Date
- 2006
- Keywords
- Diphlorethohydroxycarmalol; Diphlorethohydroxycarmalol nonaacetate; HIV-1 reverse transcriptase; Integrase; Ishige okamurae; Protease
- Citation
- Phytotherapy Research, v.20, no.8, pp 711 - 713
- Pages
- 3
- Indexed
- SCOPUS
- Journal Title
- Phytotherapy Research
- Volume
- 20
- Number
- 8
- Start Page
- 711
- End Page
- 713
- ISSN
- 0951-418X
1099-1573
- Abstract
- The bioassay-directed isolation of a marine brown alga, Ishige okamurae, afforded a carmalol derivative, diphlorethohydroxycarmalol. This compound exhibited inhibitory effects on HIV-1 reverse transcriptase and integrase with IC50 values of 9.1 μM, and 25.2 μM, respectively. However, diphlorethohydroxycarmalol did not show an inhibitory activity against HTV-1 protease. Moreover, diphlorethohydroxycarmalol nonaacetate obtained by acetylation and fucosterol failed to show any inhibitory activity against these viral enzymes. Copyright ? 2006 John Wiley & Sons, Ltd.
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Collections - 약학대학 > 약학과 > Journal Articles
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