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Inhibitory activity on HIV-1 reverse transcriptase and integrase of a carmalol derivative from a brown alga, Ishige okamurae
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| DC Field | Value | Language |
|---|---|---|
| dc.contributor.author | Ahn, M.-J. | - |
| dc.contributor.author | Yoon, K.-D. | - |
| dc.contributor.author | Kim, C.Y. | - |
| dc.contributor.author | Kim, J.H. | - |
| dc.contributor.author | Shin, C.-G. | - |
| dc.contributor.author | Kim, J. | - |
| dc.date.accessioned | 2022-12-27T07:36:17Z | - |
| dc.date.available | 2022-12-27T07:36:17Z | - |
| dc.date.issued | 2006 | - |
| dc.identifier.issn | 0951-418X | - |
| dc.identifier.issn | 1099-1573 | - |
| dc.identifier.uri | https://scholarworks.gnu.ac.kr/handle/sw.gnu/29153 | - |
| dc.description.abstract | The bioassay-directed isolation of a marine brown alga, Ishige okamurae, afforded a carmalol derivative, diphlorethohydroxycarmalol. This compound exhibited inhibitory effects on HIV-1 reverse transcriptase and integrase with IC50 values of 9.1 μM, and 25.2 μM, respectively. However, diphlorethohydroxycarmalol did not show an inhibitory activity against HTV-1 protease. Moreover, diphlorethohydroxycarmalol nonaacetate obtained by acetylation and fucosterol failed to show any inhibitory activity against these viral enzymes. Copyright ? 2006 John Wiley & Sons, Ltd. | - |
| dc.format.extent | 3 | - |
| dc.language | 영어 | - |
| dc.language.iso | ENG | - |
| dc.title | Inhibitory activity on HIV-1 reverse transcriptase and integrase of a carmalol derivative from a brown alga, Ishige okamurae | - |
| dc.type | Article | - |
| dc.publisher.location | 미국 | - |
| dc.identifier.doi | 10.1002/ptr.1939 | - |
| dc.identifier.scopusid | 2-s2.0-33747283162 | - |
| dc.identifier.bibliographicCitation | Phytotherapy Research, v.20, no.8, pp 711 - 713 | - |
| dc.citation.title | Phytotherapy Research | - |
| dc.citation.volume | 20 | - |
| dc.citation.number | 8 | - |
| dc.citation.startPage | 711 | - |
| dc.citation.endPage | 713 | - |
| dc.type.docType | Article | - |
| dc.description.isOpenAccess | N | - |
| dc.description.journalRegisteredClass | scopus | - |
| dc.subject.keywordAuthor | Diphlorethohydroxycarmalol | - |
| dc.subject.keywordAuthor | Diphlorethohydroxycarmalol nonaacetate | - |
| dc.subject.keywordAuthor | HIV-1 reverse transcriptase | - |
| dc.subject.keywordAuthor | Integrase | - |
| dc.subject.keywordAuthor | Ishige okamurae | - |
| dc.subject.keywordAuthor | Protease | - |
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