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Sulfonate chalcone as new class voltage-dependent K+ channel blocker
- Authors
- Yarishkin, Oleg V.; Ryu, Hyung Won; Park, Jae-Yong; Yang, Min Suk; Hong, Seong-Geun; Park, Ki Hun
- Issue Date
- 1-Jan-2008
- Publisher
- PERGAMON-ELSEVIER SCIENCE LTD
- Keywords
- chalcone; sulfonate chalcone; potassium channel blocker; K+ channel blocker; ion channel
- Citation
- BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, v.18, no.1, pp 137 - 140
- Pages
- 4
- Indexed
- SCIE
SCOPUS
- Journal Title
- BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Volume
- 18
- Number
- 1
- Start Page
- 137
- End Page
- 140
- ISSN
- 0960-894X
1464-3405
- Abstract
- Chalcone derivatives 1-17 were synthesized and their voltage-dependent K+ channel inhibitory activities were investigated. The effective K+ channel blockers were shown to be sulfonate chalcones 9-17, in which the sulfonyloxy group is placed on the A-ring. The 3'-(p-aminobenzene-sulfonylhydroxy)-4-hydroxychalcone 17 (IC50 = 0.51 +/- 0.05 mu M) was the most potent K+ channel blocker. (C) 2007 Elsevier Ltd. All rights reserved.
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