ScholarWorks@Gyeongsang National University

Detailed Information

Cited 59 time in webofscience Cited 0 time in scopus
Metadata Downloads

Sulfonate chalcone as new class voltage-dependent K+ channel blocker

Full metadata record
DC Field Value Language
dc.contributor.authorYarishkin, Oleg V.-
dc.contributor.authorRyu, Hyung Won-
dc.contributor.authorPark, Jae-Yong-
dc.contributor.authorYang, Min Suk-
dc.contributor.authorHong, Seong-Geun-
dc.contributor.authorPark, Ki Hun-
dc.date.accessioned2022-12-27T06:17:47Z-
dc.date.available2022-12-27T06:17:47Z-
dc.date.issued2008-01-01-
dc.identifier.issn0960-894X-
dc.identifier.issn1464-3405-
dc.identifier.urihttps://scholarworks.gnu.ac.kr/handle/sw.gnu/27530-
dc.description.abstractChalcone derivatives 1-17 were synthesized and their voltage-dependent K+ channel inhibitory activities were investigated. The effective K+ channel blockers were shown to be sulfonate chalcones 9-17, in which the sulfonyloxy group is placed on the A-ring. The 3'-(p-aminobenzene-sulfonylhydroxy)-4-hydroxychalcone 17 (IC50 = 0.51 +/- 0.05 mu M) was the most potent K+ channel blocker. (C) 2007 Elsevier Ltd. All rights reserved.-
dc.format.extent4-
dc.language영어-
dc.language.isoENG-
dc.publisherPERGAMON-ELSEVIER SCIENCE LTD-
dc.titleSulfonate chalcone as new class voltage-dependent K+ channel blocker-
dc.typeArticle-
dc.publisher.location영국-
dc.identifier.doi10.1016/j.bmcl.2007.10.114-
dc.identifier.wosid000253720300021-
dc.identifier.bibliographicCitationBIOORGANIC & MEDICINAL CHEMISTRY LETTERS, v.18, no.1, pp 137 - 140-
dc.citation.titleBIOORGANIC & MEDICINAL CHEMISTRY LETTERS-
dc.citation.volume18-
dc.citation.number1-
dc.citation.startPage137-
dc.citation.endPage140-
dc.type.docTypeArticle-
dc.description.isOpenAccessN-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.relation.journalResearchAreaPharmacology & Pharmacy-
dc.relation.journalResearchAreaChemistry-
dc.relation.journalWebOfScienceCategoryChemistry, Medicinal-
dc.relation.journalWebOfScienceCategoryChemistry, Organic-
dc.subject.keywordPlusPOTASSIUM CHANNEL-
dc.subject.keywordPlusDERIVATIVES-
dc.subject.keywordPlusEXPRESSION-
dc.subject.keywordPlusCELLS-
dc.subject.keywordAuthorchalcone-
dc.subject.keywordAuthorsulfonate chalcone-
dc.subject.keywordAuthorpotassium channel blocker-
dc.subject.keywordAuthorK+ channel blocker-
dc.subject.keywordAuthorion channel-
Files in This Item
There are no files associated with this item.
Appears in
Collections
College of Medicine > Department of Medicine > Journal Articles
Show simple item record

qrcode

Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.

Altmetrics

Total Views & Downloads

RSS_1.0 RSS_2.0 ATOM_1.0

Gyeongsang National University Central Library, 501, Jinju-daero, Jinju-si, Gyeongsangnam-do, 52828, Republic of Korea+82-55-772-0532

COPYRIGHT 2022 GYEONGSANG NATIONAL UNIVERSITY LIBRARY. ALL RIGHTS RESERVED.

Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.

BROWSE

한국어