NEUROPROTECTIVE EFFECT OF VITAMIN C AGAINST PTZ INDUCED APOPTOTIC NEURODEGENERATION IN ADULT RAT BRAIN
- Authors
- Naseer, Muhammad Imran; Ullah, Ikram; Ullah, Najeeb; Lee, Hae Young; Cheon, Eun Woo; Chung, Jongil; Kim, Myeong Ok
- Issue Date
- Jul-2011
- Publisher
- UNIV KARACHI
- Keywords
- PTZ; neurodegeneration; vitamin C; adult rat brain
- Citation
- PAKISTAN JOURNAL OF PHARMACEUTICAL SCIENCES, v.24, no.3, pp.263 - 268
- Indexed
- SCIE
SCOPUS
- Journal Title
- PAKISTAN JOURNAL OF PHARMACEUTICAL SCIENCES
- Volume
- 24
- Number
- 3
- Start Page
- 263
- End Page
- 268
- URI
- https://scholarworks.bwise.kr/gnu/handle/sw.gnu/23668
- ISSN
- 1011-601X
- Abstract
- The present study was designed to observe the effect of PTZ on expression of caspsae-3, and to evaluate the neuroprotective role of vitamin C (vit-C) against PTZ-induced apoptotic neurodegeneration in adult rat brain. We observed that administration of a single conclusive dose of pentylenetetrazol (PTZ 50mg/kg) in adults rats induced epileptic seizure and increased activation of caspase-3 and caused neuronal death. Further, rats were injected with vit-C (250 mg/kg) 30 min before PTZ injection. The protective effect of vit-C against PTZ-induced apoptotic neurodegeneration in adult rat brain was observed using Western blot analysis and Nissl staining. The results showed that conclusive dose of PTZ-induced seizure, increased expression of caspase-3 and neuronal apoptosis in adult rat brain. Whereas, the pretreatment of vit-C along with PTZ showed significantly decreased expression of caspase-3 as compare to control group. Finally, our results indicated that vit-C can prevent some of the deleterious effect of seizure and neuronal degeneration induced by PTZ in adult rat brain.
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