Pro- and anti-inflammatory cytokine expression and histopathological characteristics in canine brain with traumatic brain injuryopen access
- Authors
- Yu, Chi-Ho; Yhee, Ji-Young; Kim, Jong-Hyuk; Im, Keum-Soon; Kim, Na-Hyun; Jung, Dong-In; Lee, Hee-Chun; Chon, Seung-Ki; Sur, Jung-Hyang
- Issue Date
- Sep-2011
- Publisher
- KOREAN SOC VETERINARY SCIENCE
- Keywords
- interleukin-1; interleukin-6; transforming growth factor-beta; traumatic brain injury; tumor necrosis factor-alpha
- Citation
- JOURNAL OF VETERINARY SCIENCE, v.12, no.3, pp.299 - 301
- Indexed
- SCIE
SCOPUS
KCI
- Journal Title
- JOURNAL OF VETERINARY SCIENCE
- Volume
- 12
- Number
- 3
- Start Page
- 299
- End Page
- 301
- URI
- https://scholarworks.bwise.kr/gnu/handle/sw.gnu/23582
- DOI
- 10.4142/jvs.2011.12.3.299
- ISSN
- 1229-845X
- Abstract
- We analyzed the expression level and cellular localization of pro- and anti-inflammatory cytokines and histopathologically characterized canine traumatic brain injury (TBI). Canine TBI brains revealed subarachnoid and cerebral cortical hemorrhage, neutrophilic infiltration, neuronal necrosis, astrocytosis, and vasogenic edema. Immunohistochemical evaluations suggested that both pro-inflammatory cytokines [interleukin (IL)-1 beta, IL-6, and tumor necrosis factor-alpha] and anti-inflammatory cytokines [IL-10 and transforming growth factor-beta (TGF-beta)] were highly expressed in neurons and neutrophils. In particular, the highest magnitude of expression was identified for IL-1 beta and TGF-beta. This data helps describe the pathologic characteristics of canine TBI, and may help in the design of potential therapeutic approaches to control secondary damage by inflammatory cytokines.
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Collections - 수의과대학 > Department of Veterinary Medicine > Journal Articles
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