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Design and synthesis of triazolopyridazines substituted with methylisoquinolinone as selective c-Met kinase inhibitors
- Authors
- Ryu, Jae Wook; Han, Sun-Young; Yun, Jeong In; Choi, Sang-Un; Jung, Heejung; Du Ha, Jae; Cho, Sung Yun; Lee, Chong Ock; Kang, Nam Sook; Koh, Jong Sung; Kim, Hyoung Rae; Lee, Jongkook
- Issue Date
- Dec-2011
- Publisher
- Pergamon Press Ltd.
- Keywords
- c-Met; Cancer; Kinase inhibitor; Triazolopyridazine; Methylisoquinolinone
- Citation
- Bioorganic & Medicinal Chemistry Letters, v.21, no.23, pp 7185 - 7188
- Pages
- 4
- Indexed
- SCI
SCIE
SCOPUS
- Journal Title
- Bioorganic & Medicinal Chemistry Letters
- Volume
- 21
- Number
- 23
- Start Page
- 7185
- End Page
- 7188
- ISSN
- 0960-894X
1464-3405
- Abstract
- A series of triazolopyridazines substituted with methylisoquinolinone were designed and synthesized. Some of the triazolopyridazines strongly inhibited c-Met kinase and showed good anti-proliferative activity against a panel of c-Met-amplified gastric cancer cell lines (MKN-45, SNU-5 and Hs746T). (C) 2011 Elsevier Ltd. All rights reserved.
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