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Cited 15 time in webofscience Cited 17 time in scopus
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Design and synthesis of triazolopyridazines substituted with methylisoquinolinone as selective c-Met kinase inhibitors

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dc.contributor.authorRyu, Jae Wook-
dc.contributor.authorHan, Sun-Young-
dc.contributor.authorYun, Jeong In-
dc.contributor.authorChoi, Sang-Un-
dc.contributor.authorJung, Heejung-
dc.contributor.authorDu Ha, Jae-
dc.contributor.authorCho, Sung Yun-
dc.contributor.authorLee, Chong Ock-
dc.contributor.authorKang, Nam Sook-
dc.contributor.authorKoh, Jong Sung-
dc.contributor.authorKim, Hyoung Rae-
dc.contributor.authorLee, Jongkook-
dc.date.accessioned2022-12-27T02:50:10Z-
dc.date.available2022-12-27T02:50:10Z-
dc.date.issued2011-12-
dc.identifier.issn0960-894X-
dc.identifier.issn1464-3405-
dc.identifier.urihttps://scholarworks.gnu.ac.kr/handle/sw.gnu/23431-
dc.description.abstractA series of triazolopyridazines substituted with methylisoquinolinone were designed and synthesized. Some of the triazolopyridazines strongly inhibited c-Met kinase and showed good anti-proliferative activity against a panel of c-Met-amplified gastric cancer cell lines (MKN-45, SNU-5 and Hs746T). (C) 2011 Elsevier Ltd. All rights reserved.-
dc.format.extent4-
dc.language영어-
dc.language.isoENG-
dc.publisherPergamon Press Ltd.-
dc.titleDesign and synthesis of triazolopyridazines substituted with methylisoquinolinone as selective c-Met kinase inhibitors-
dc.typeArticle-
dc.publisher.location영국-
dc.identifier.doi10.1016/j.bmcl.2011.09.066-
dc.identifier.scopusid2-s2.0-80255138845-
dc.identifier.wosid000296717600051-
dc.identifier.bibliographicCitationBioorganic & Medicinal Chemistry Letters, v.21, no.23, pp 7185 - 7188-
dc.citation.titleBioorganic & Medicinal Chemistry Letters-
dc.citation.volume21-
dc.citation.number23-
dc.citation.startPage7185-
dc.citation.endPage7188-
dc.type.docTypeArticle-
dc.description.isOpenAccessN-
dc.description.journalRegisteredClasssci-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.relation.journalResearchAreaPharmacology & Pharmacy-
dc.relation.journalResearchAreaChemistry-
dc.relation.journalWebOfScienceCategoryChemistry, Medicinal-
dc.relation.journalWebOfScienceCategoryChemistry, Organic-
dc.subject.keywordPlusCANCER-
dc.subject.keywordPlusDISCOVERY-
dc.subject.keywordPlusAMPLIFICATION-
dc.subject.keywordPlusSENSITIVITY-
dc.subject.keywordPlusONCOGENE-
dc.subject.keywordPlusRECEPTOR-
dc.subject.keywordAuthorc-Met-
dc.subject.keywordAuthorCancer-
dc.subject.keywordAuthorKinase inhibitor-
dc.subject.keywordAuthorTriazolopyridazine-
dc.subject.keywordAuthorMethylisoquinolinone-
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