Protective Effects of 3,4-seco-lupane Type Triterpenes from Acanthopanax senticosus against Advanced Glycation Endproducts

Abstract

Advanced glycation end products (AGEs) are thought to be directly involved in diabetes mellitus and aging. In this study, the protective activities of 3,4-seco-lupane type triterpenes (chiisanogenin and chiisanoside) from Acanthopanax senticosus against the formation of AGEs were examined using in vitro glycation reactions. Of the two isolated compounds, chiisanogenin exhibited strong inhibitory activity against the formation of AGEs. The inhibitory activity of chiisanogenin was similar level in 50 mu M treatment with the AGE inhibitor aminoguanidine, which was used as a positive control. These results suggest that chiisanogenin from A. senticosus is a bioactive component that contributes to glycation-associated diseases.