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Characterization and Anti-inflammatory Effects of Iodinated Acetylenic Acids Isolated from the Marine Sponges Suberites mammilaris and Suberites japonicus
- Authors
- Hwang, Buyng Su; Lee, Kyung; Yang, Cao; Jeong, Eun Ju; Rho, Jung-Rae
- Issue Date
- Dec-2013
- Publisher
- AMER CHEMICAL SOC
- Citation
- JOURNAL OF NATURAL PRODUCTS, v.76, no.12, pp 2355 - 2359
- Pages
- 5
- Indexed
- SCI
SCIE
SCOPUS
- Journal Title
- JOURNAL OF NATURAL PRODUCTS
- Volume
- 76
- Number
- 12
- Start Page
- 2355
- End Page
- 2359
- ISSN
- 0163-3864
1520-6025
- Abstract
- The previously unknown compounds 1-4, acetylenic acids with one or two iodine atom(s), were isolated from the marine sponges Suberites mammilaris and Suberites japonicus. Their complete structures were determined using NMR and mass spectrometry. The methylated compounds la and 2a exhibited a strong NO inhibitory effect on RAW264.7 cells, while methylated 3a and 4a were inactive in RAW264.7 cells, but highly active in BV2 microglia cells.
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