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Protective effect of aquacultured flounder fish-derived peptide against oxidative stress in zebrafish
- Authors
- Ko, Ju-Young; Kim, Eun-A.; Lee, Ji-Hyeok; Kang, Min-Cheol; Lee, Jung-Suck; Kim, Jin-Soo; Jung, Won-Kyo; Jeon, You-Jin
- Issue Date
- Jan-2014
- Publisher
- ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
- Keywords
- Zebrafish; Oxidative stress; Antioxidative peptide; In vivo model; AAPH
- Citation
- FISH & SHELLFISH IMMUNOLOGY, v.36, no.1, pp 320 - 323
- Pages
- 4
- Indexed
- SCI
SCIE
SCOPUS
- Journal Title
- FISH & SHELLFISH IMMUNOLOGY
- Volume
- 36
- Number
- 1
- Start Page
- 320
- End Page
- 323
- ISSN
- 1050-4648
1095-9947
- Abstract
- This study investigates the protective effect of aquacultured flounder fish-derived peptide (AFFP) against 2,2-azobis-(2-amidinopropane) hydrochloride (AAPH)-induced oxidative damage in a zebrafish model. Zebrafish embryos were evaluated for the protective effect by heartbeat rate, survival rate, ROS generation, lipid peroxidation, and cell death. In the results, the AAPH group showed a low survival rate, whereas the AFFP and AAPH co-treated group increased a survival rate. Also, AFFP dose-dependently reduced AAPH-induced intracellular ROS and lipid peroxidation, and decreased cell death in AAPH-induced zebrafish. These results revealed that AFFP could be used as a natural antioxidant, and that the zebrafish provides an alternative in vivo model to efficiently evaluate the antioxidative effects of peptides on fishes. (C) 2013 Elsevier Ltd. All rights reserved.
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