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An optimized extraction technique for acetylcholinesterase inhibitors from the Camellia japonica seed cake by using response surface methodology
- Authors
- Kim, Jae Kyeom; Kim, Cho Rong; Lim, Ho-Jeong; Nam, Sang Hae; Joo, Ok Soo; Shin, Dong-Hoon; Shin, Eui-Cheol
- Issue Date
- Jul-2014
- Publisher
- Japan Society for Bioscience Biotechnology and Agrochemistry/Nippon Nogeikagaku Kai
- Keywords
- Camellia japonica; camellia seed cake; acetylcholinesterase; Alzheimer's disease; response surface methodology
- Citation
- Bioscience, Biotechnology and Biochemistry, v.78, no.7, pp 1237 - 1241
- Pages
- 5
- Indexed
- SCI
SCIE
SCOPUS
- Journal Title
- Bioscience, Biotechnology and Biochemistry
- Volume
- 78
- Number
- 7
- Start Page
- 1237
- End Page
- 1241
- ISSN
- 0916-8451
1347-6947
- Abstract
- The response surface methodology (RSM) was used to optimize the extraction conditions for the acetylcholinesterase (AchE) inhibitory activity and extraction yield from Camellia japonica seed cake. Predicted values for AchE inhibition and extraction yield were 19.41 and 13.35%, respectively, which are in good agreement with the experimental values from validation, suggesting that RSM may provide a useful tool to optimization processes.
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