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Development of an Advanced Synthetic Route to Macrosphelides and Its Application to the Discovery of a More Potent Macrosphelide Derivativeopen access
- Issue Date
- Oct-2014
- Publisher
- MDPI
- Keywords
- macrosphelides; natural product; total synthesis
- Citation
- MOLECULES, v.19, no.10, pp 15572 - 15583
- Pages
- 12
- Indexed
- SCIE
SCOPUS
- Journal Title
- MOLECULES
- Volume
- 19
- Number
- 10
- Start Page
- 15572
- End Page
- 15583
- ISSN
- 1420-3049
- Abstract
- The discovery of a more cytotoxic macrosphelide derivative, including its total synthesis and bioassay are described. Application of the Koide protocol to a readily available propagylic alcohol allowed the rapid and practical synthesis of a macrosphelide A skeleton. This strategy enabled the successful improvement of the cytotoxic activity of the macrosphelide derivative.
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