Detailed Information
Cited 24 time in 
Cited 28 time in 
Cited 28 time in
Metadata Downloads
Expression of neurotrophic factors in injured spinal cord after transplantation of human-umbilical cord blood stem cells in ratsopen access
- Authors
- Chung, Hyo-jin; Chung, Wook-hun; Lee, Jae-Hoon; Chung, Dai-Jung; Yang, Wo-Jong; Lee, A-Jin; Choi, Chi-Bong; Chang, Hwa-Seok; Kim, Dae-Hyun; Suh, Hyun Jung; Lee, Dong-Hun; Hwang, Soo-Han; Do, Sun Hee; Kim, Hwi-Yool
- Issue Date
- Mar-2016
- Publisher
- KOREAN SOC VETERINARY SCIENCE
- Keywords
- brain-derived neurotrophic factor; nerve growth factor; neurotrophic factor; neurotrophin-3; spinal cord injury
- Citation
- JOURNAL OF VETERINARY SCIENCE, v.17, no.1, pp.97 - 102
- Indexed
- SCIE
SCOPUS
KCI
- Journal Title
- JOURNAL OF VETERINARY SCIENCE
- Volume
- 17
- Number
- 1
- Start Page
- 97
- End Page
- 102
- ISSN
- 1229-845X
- Abstract
- We induced percutaneous spinal cord injuries (SCI) using a balloon catheter in 45 rats and transplanted human umbilical cord blood derived mesenchymal stem cells (hUCB-MSCs) at the injury site. Locomotor function was significantly improved in hUCB-MSCs transplanted groups. Quantitative ELISA of extract from entire injured spinal cord showed increased expression of brain-derived neurotrophic factor (BDNF), nerve growth factor (NGF) and neurotrophin-3 (NT-3). Our results show that treatment of SCI with hUCB-MSCs can improve locomotor functions, and suggest that increased levels of BDNF, NGF and NT-3 in the injured spinal cord were the main therapeutic effect.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - 수의과대학 > Department of Veterinary Medicine > Journal Articles
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.