Detailed Information

Cited 6 time in webofscience Cited 7 time in scopus
Metadata Downloads

Hair Growth-Promoting Activities of Glycosaminoglycans Extracted from the Tunics of Ascidian (Halocynthia roretzi)open access

Authors
Neri, Therese Ariane N.Palmos, Grace N.Park, Shin YoungJung, Tae SungChoi, Byeong-Dae
Issue Date
Mar-2022
Publisher
MDPI
Keywords
ascidian tunic; glycosaminoglycans; hair follicle; C57BL; 6 mice; hair growth
Citation
POLYMERS, v.14, no.6
Indexed
SCIE
SCOPUS
Journal Title
POLYMERS
Volume
14
Number
6
URI
https://scholarworks.gnu.ac.kr/handle/sw.gnu/1553
DOI
10.3390/polym14061096
ISSN
2073-4360
2073-4360
Abstract
Throughout the ages, hair has had psychological and sociological importance in framing the personality and general appearance of an individual. Despite efforts to solve this problem, no groundbreaking measures have been proposed. Glycosaminoglycans (GAGs) and associated proteoglycans have important functions in homeostatic maintenance and regenerative processes of the skin. However, little is known about the role of these molecules in the regulation of the hair follicle cycle. Three fractions (F1, F2 and F3) were obtained after separation and purification of GAGs from ascidian tunics. F1 was observed to contain a small amount of amino sugar while high contents of galactose and N-acetylglucosamine were noted in F2 and F3. 2-acetamido-2-deoxy-3-O-(beta-D-gluco-4-enepyranosyluronic acid)-6-O-sulfo-D-galactose ( increment Di-6S) and 2-acetamido-2-deoxy-3-O-(beta-D-gluco-4-enepyranosyluronic acid)-4-O-sulfo-D-galactose ( increment Di-4S) were the main disaccharide components. F3 exhibited the highest proliferation activity on human follicle dermal papilla (HFDP) cells. In addition, mixed samples (FFM) of F2 and F3 at different concentrations showed peak activities for five days. After cell culture at a concentration of 10 mg/mL and dihydrotestosterone (DHT), the inhibition effect was higher than that for Minoxidil. Application of 10 mg of FFM to the hair of mice for 28 days resulted in a hair growth effect similar to that of Minoxidil, a positive control.
Files in This Item
There are no files associated with this item.
Appears in
Collections
수의과대학 > Department of Veterinary Medicine > Journal Articles
해양과학대학 > Seafood science & Technology > Journal Articles

qrcode

Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.

Related Researcher

Researcher Park, Shin Young photo

Park, Shin Young
해양과학대학 (해양식품공학과)
Read more

Altmetrics

Total Views & Downloads

BROWSE