Healthy ageing of cloned sheepopen access
- Authors
- Sinclair, K. D.; Corr, S. A.; Gutierrez, C. G.; Fisher, P. A.; Lee, J. -H.; Rathbone, A. J.; Choi, I.; Campbell, K. H. S.; Gardner, D. S.
- Issue Date
- Jul-2016
- Publisher
- NATURE PUBLISHING GROUP
- Citation
- NATURE COMMUNICATIONS, v.7
- Indexed
- SCIE
SCOPUS
- Journal Title
- NATURE COMMUNICATIONS
- Volume
- 7
- URI
- https://scholarworks.bwise.kr/gnu/handle/sw.gnu/15389
- DOI
- 10.1038/ncomms12359
- ISSN
- 2041-1723
- Abstract
- The health of cloned animals generated by somatic-cell nuclear transfer (SCNT) has been of concern since its inception; however, there are no detailed assessments of late-onset, non-communicable diseases. Here we report that SCNT has no obvious detrimental long-term health effects in a cohort of 13 cloned sheep. We perform musculoskeletal assessments, metabolic tests and blood pressure measurements in 13 aged (7-9 years old) cloned sheep, including four derived from the cell line that gave rise to Dolly. We also perform radiological examinations of all main joints, including the knees, the joint most affected by osteoarthritis in Dolly, and compare all health parameters to groups of 5- and 6-year-old sheep, and published reference ranges. Despite their advanced age, these clones are euglycaemic, insulin sensitive and normotensive. Importantly, we observe no clinical signs of degenerative joint disease apart from mild, or in one case moderate, osteoarthritis in some animals. Our study is the first to assess the long-term health outcomes of SCNT in large animals.
- Files in This Item
- There are no files associated with this item.
- Appears in
Collections - 농업생명과학대학 > 동물생명융합학부 > Journal Articles
![qrcode](https://api.qrserver.com/v1/create-qr-code/?size=55x55&data=https://scholarworks.gnu.ac.kr/handle/sw.gnu/15389)
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.