Lonicera japonica Thunb. Induces caspase-dependent apoptosis through death receptors and suppression of AKT in U937 human leukemic cells
- Authors
- Park, Cheol; Lee, Won Sup; Han, Min-Ho; Song, Kyoung Seob; Hong, Su-Hyun; Nagappan, Arulkumar; Kim, Gi-Young; Kim, Gon Sup; Jung, Jin-Myung; Ryu, Chung Ho; Shin, Sung Chul; Hong, Soon Chan; Choi, Yung Hyun
- Issue Date
- Mar-2018
- Publisher
- WILEY
- Keywords
- Akt; cytokines; death Receptor 4; Lonicera japonica Thunb; U937 cells
- Citation
- PHYTOTHERAPY RESEARCH, v.32, no.3, pp.504 - 513
- Indexed
- SCIE
SCOPUS
- Journal Title
- PHYTOTHERAPY RESEARCH
- Volume
- 32
- Number
- 3
- Start Page
- 504
- End Page
- 513
- URI
- https://scholarworks.bwise.kr/gnu/handle/sw.gnu/11894
- DOI
- 10.1002/ptr.5996
- ISSN
- 0951-418X
- Abstract
- Decoctions obtained from the dried flowers of Lonicera japonica Thunb. (Indongcho) have been utilized in folk remedies against inflammatory diseases. Recently, many agents that have used for inflammatory diseases are showing anticancer effects. Here, we have isolated polyphenols extracted from lyophilized Lonicera japonica Thunb (PELJ) and investigated the anticancer effects of PELJ on U937 cells. Here, we demonstrated that PELJ induced apoptosis by upregulation of DR4 and Fas, and further it is augmented by suppression of XIAP. In addition, The PELJ-induced apoptosis is at least in part by blocking PI3K/Akt pathway. These findings suggest that PELJ may provide evidence of anticancer activities on U937 cells. Further study for detailed mechanism and the effects on animal models is warranted to determine whether PELJ provide more conclusive evidence that PELJ which may provide a beneficial effect for treating cancer.
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Collections - 수의과대학 > Department of Veterinary Medicine > Journal Articles
- College of Medicine > Department of Medicine > Journal Articles
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