Lonicera japonica Thunb. Induces caspase-dependent apoptosis through death receptors and suppression of AKT in U937 human leukemic cells
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Park, Cheol | - |
dc.contributor.author | Lee, Won Sup | - |
dc.contributor.author | Han, Min-Ho | - |
dc.contributor.author | Song, Kyoung Seob | - |
dc.contributor.author | Hong, Su-Hyun | - |
dc.contributor.author | Nagappan, Arulkumar | - |
dc.contributor.author | Kim, Gi-Young | - |
dc.contributor.author | Kim, Gon Sup | - |
dc.contributor.author | Jung, Jin-Myung | - |
dc.contributor.author | Ryu, Chung Ho | - |
dc.contributor.author | Shin, Sung Chul | - |
dc.contributor.author | Hong, Soon Chan | - |
dc.contributor.author | Choi, Yung Hyun | - |
dc.date.accessioned | 2022-12-26T17:16:27Z | - |
dc.date.available | 2022-12-26T17:16:27Z | - |
dc.date.created | 2022-12-13 | - |
dc.date.issued | 2018-03 | - |
dc.identifier.issn | 0951-418X | - |
dc.identifier.uri | https://scholarworks.bwise.kr/gnu/handle/sw.gnu/11894 | - |
dc.description.abstract | Decoctions obtained from the dried flowers of Lonicera japonica Thunb. (Indongcho) have been utilized in folk remedies against inflammatory diseases. Recently, many agents that have used for inflammatory diseases are showing anticancer effects. Here, we have isolated polyphenols extracted from lyophilized Lonicera japonica Thunb (PELJ) and investigated the anticancer effects of PELJ on U937 cells. Here, we demonstrated that PELJ induced apoptosis by upregulation of DR4 and Fas, and further it is augmented by suppression of XIAP. In addition, The PELJ-induced apoptosis is at least in part by blocking PI3K/Akt pathway. These findings suggest that PELJ may provide evidence of anticancer activities on U937 cells. Further study for detailed mechanism and the effects on animal models is warranted to determine whether PELJ provide more conclusive evidence that PELJ which may provide a beneficial effect for treating cancer. | - |
dc.language | 영어 | - |
dc.language.iso | en | - |
dc.publisher | WILEY | - |
dc.subject | MITOCHONDRIAL-MEMBRANE PERMEABILIZATION | - |
dc.subject | CYTOCHROME-C | - |
dc.subject | CANCER CELLS | - |
dc.subject | PATHWAY | - |
dc.subject | PI3K/AKT | - |
dc.subject | PROTEIN | - |
dc.subject | CLEAVAGE | - |
dc.subject | NECROSIS | - |
dc.subject | FRUIT | - |
dc.subject | BCL-2 | - |
dc.title | Lonicera japonica Thunb. Induces caspase-dependent apoptosis through death receptors and suppression of AKT in U937 human leukemic cells | - |
dc.type | Article | - |
dc.contributor.affiliatedAuthor | Lee, Won Sup | - |
dc.contributor.affiliatedAuthor | Kim, Gon Sup | - |
dc.contributor.affiliatedAuthor | Jung, Jin-Myung | - |
dc.identifier.doi | 10.1002/ptr.5996 | - |
dc.identifier.scopusid | 2-s2.0-85036495454 | - |
dc.identifier.wosid | 000426745800014 | - |
dc.identifier.bibliographicCitation | PHYTOTHERAPY RESEARCH, v.32, no.3, pp.504 - 513 | - |
dc.relation.isPartOf | PHYTOTHERAPY RESEARCH | - |
dc.citation.title | PHYTOTHERAPY RESEARCH | - |
dc.citation.volume | 32 | - |
dc.citation.number | 3 | - |
dc.citation.startPage | 504 | - |
dc.citation.endPage | 513 | - |
dc.type.rims | ART | - |
dc.type.docType | Article | - |
dc.description.journalClass | 1 | - |
dc.description.journalRegisteredClass | scie | - |
dc.description.journalRegisteredClass | scopus | - |
dc.relation.journalResearchArea | Pharmacology & Pharmacy | - |
dc.relation.journalWebOfScienceCategory | Chemistry, Medicinal | - |
dc.relation.journalWebOfScienceCategory | Pharmacology & Pharmacy | - |
dc.subject.keywordPlus | MITOCHONDRIAL-MEMBRANE PERMEABILIZATION | - |
dc.subject.keywordPlus | CYTOCHROME-C | - |
dc.subject.keywordPlus | CANCER CELLS | - |
dc.subject.keywordPlus | PATHWAY | - |
dc.subject.keywordPlus | PI3K/AKT | - |
dc.subject.keywordPlus | PROTEIN | - |
dc.subject.keywordPlus | CLEAVAGE | - |
dc.subject.keywordPlus | NECROSIS | - |
dc.subject.keywordPlus | FRUIT | - |
dc.subject.keywordPlus | BCL-2 | - |
dc.subject.keywordAuthor | Akt | - |
dc.subject.keywordAuthor | cytokines | - |
dc.subject.keywordAuthor | death Receptor 4 | - |
dc.subject.keywordAuthor | Lonicera japonica Thunb | - |
dc.subject.keywordAuthor | U937 cells | - |
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.
Gyeongsang National University Central Library, 501, Jinju-daero, Jinju-si, Gyeongsangnam-do, 52828, Republic of Korea+82-55-772-0533
COPYRIGHT 2022 GYEONGSANG NATIONAL UNIVERSITY LIBRARY. ALL RIGHTS RESERVED.
Certain data included herein are derived from the © Web of Science of Clarivate Analytics. All rights reserved.
You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.