상세 보기
Ovataline: A Polyketide Isolated from the Benthic Dinoflagellate Ostreopsis cf. ovata with 5 alpha-Reductase Inhibitory Activity in RWPE-1 Prostatic Cells
- Lee, Sangbum;
- Moon, Seung Joo;
- Du Yoo, Yeong;
- Hwang, Byung Su;
- Jeong, Eun Ju;
- 외 1명
Citations
WEB OF SCIENCE
3Citations
SCOPUS
3초록
Ovataline (1), which is a polar metabolite containing a hexahydroquinoline moiety, was isolated from cultures of the marine dinoflagellate Ostreopsis cf. ovata. 1 was characterized as a zwitterionic compound with hexahydroquinoline and tetrahydropyran rings. The configurations of the chiral centers in 1 were established using ROESY correlations, Piased configurational and Mosher reaction analyses, and density functional theory calculations. 1 exhibited a 78% (1 mu M) inhibition of type II 5 alpha-reductase in testosterone propionate-induced RWPE-1 human prostatic cells.
키워드
URINARY-TRACT SYMPTOMS; JEJU ISLAND; HYPERPLASIA; WATERS
- 제목
- Ovataline: A Polyketide Isolated from the Benthic Dinoflagellate Ostreopsis cf. ovata with 5 alpha-Reductase Inhibitory Activity in RWPE-1 Prostatic Cells
- 저자
- Lee, Sangbum; Moon, Seung Joo; Du Yoo, Yeong; Hwang, Byung Su; Jeong, Eun Ju; Rho, Jung-Rae
- 발행일
- 2022-06
- 유형
- Article
- 저널명
- Organic Letters
- 권
- 24
- 호
- 23
- 페이지
- 4182 ~ 4186