상세 보기
국내산 초피와 산초의 산업적 활용 가능성: 고당으로 유도된 뇌신경세포 독성에 대한 추출물의 보호 효과
- Han, H.J.;
- Park, S.K.;
- Kim, M.J.;
- An, J.W.;
- Lee, S.J.;
- ... Heo, H.J.;
- 외 2명
SCOPUS
6초록
This study focused on the in vitro investigation of antioxidant and anti-diabetic activities, along with neuroprotection against high glucose-induced cytotoxicity, in order to evaluate the physiological effects of Zanthoxylum piperitum and Zanthoxylum schinifolium. The highest total phenolic content was measured in the 40% ethanolic extracts of Zanthoxylum piperitum (EZP) and Zanthoxylum schinifolium (EZS). The in vitro EZP antioxidant activity showed a relatively higher ABTS/DPPH radical scavenging activity and malondialdehyde inhibitory effect than that of EZS. The EZP inhibited carbohydrate hydrolysis (α-glucosidase and α-amylase) more efficiently than EZS in anti-diabetic tests. However, EZS showed a more efficient inhibition of advanced glycation end-products formation than EZP. In addition, both EZP and EZS effectively protected human-derived neuronal cells from high glucose-induced cytotoxicity. Finally, the physiological compounds were analyzed using UPLC IMS-QTOF/MSE, and the main EZP (quercetin-3-O-glucoside and 3- caffeoylquinic acid) and EZS (5-caffeoylquinic acid) compounds were identified as phenolic compounds. ? 2020 The Korean Society of Food Science and Technology.
키워드
- 제목
- 국내산 초피와 산초의 산업적 활용 가능성: 고당으로 유도된 뇌신경세포 독성에 대한 추출물의 보호 효과
- 제목 (타언어)
- Industrial potential of domestic zanthoxylum piperitum and zanthoxylum schinifolium: Protective effect of both extracts on high glucose-induced neurotoxicity
- 저자
- Han, H.J.; Park, S.K.; Kim, M.J.; An, J.W.; Lee, S.J.; Kang, J.Y.; Kim, J.M.; Heo, H.J.
- 발행일
- 2020-06
- 유형
- Article
- 저널명
- 한국식품과학회지
- 권
- 52
- 호
- 3
- 페이지
- 274 ~ 283