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활성 산소종으로 야기된 산화스트레스에 대한 와송 추출물의 신경세포 보호효과 및 주요 생리활성물질
- Park, S.B.;
- Lee, D.S.;
- Kang, J.Y.;
- Kim, J.M.;
- Park, S.K.;
- ... Heo, H.J.;
- 외 5명
SCOPUS
7초록
The study aimed to investigate the antioxidant activity and neuroprotective effect of the ethyl acetate fraction from Orostachys japonicus A. Berger extract (EFOJ) and its main constituent compounds. Among all fractions, the highest content of total phenolics was found in EFOJ. The antioxidant activity of EFOJ was confirmed through the 2,2-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid (ABTS), 1-1-diphenyl-2-picryl-hydrazyl (DPPH), ferric reducing antioxidant power (FRAP) assays and the inhibitory effect of malondialdehyde (MDA). In addition, we ascertained that EFOJ not only decreased the intracellular ROS level, but also protected the neuronal cells against H2O2-induced oxidative stress. In liquid chromatography-mass spectrometry analysis, the following were found to be the main compounds of EFOJ: quercetin-3O-glucoside, kaempferol-3-O-rutinoside, kaempferol-3-O-glucoside, and kaempferol-3-O-rhamnoside. Consequently, these results suggested that the protective effect on neuronal cells was based on the antioxidant activities of the physiologically active compounds of Orostachys japonicus A. Berger extract, which could therefore help to mitigate neurodegenerative diseases.
키워드
- 제목
- 활성 산소종으로 야기된 산화스트레스에 대한 와송 추출물의 신경세포 보호효과 및 주요 생리활성물질
- 제목 (타언어)
- Protective effect on neuronal cells of Orostachys japonicus A. Berger extract against reactive oxygen species-induced neuronal cytotoxicity and active compounds
- 저자
- Park, S.B.; Lee, D.S.; Kang, J.Y.; Kim, J.M.; Park, S.K.; Kang, J.E.; Kwon, B.S.; Park, S.H.; Lee, C.J.; Lee, U.; Heo, H.J.
- 발행일
- 2017-10
- 유형
- Article
- 저널명
- 한국식품과학회지
- 권
- 49
- 호
- 5
- 페이지
- 524 ~ 531
- 언어
- KOR
- 출판사
- 한국식품과학회
- 발행국가
- 대한민국
- 분량
- 8 페이지
- ISSN
- P 0367-6293