Flavones: The Apoptosis in Prostate Cancer of Three Flavones Selected as Therapeutic Candidate Models
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초록

Cancer is a widespread but dangerous disease that can strike anyone and is the second 1leading cause of death worldwide. Prostate cancer, in particular, is a prevalent cancer that occurs in men, and much research is being done on its treatment. Although chemical drugs are effective, they have various side effects, and accordingly, anticancer drugs using natural products are emerging. To date, many natural candidates have been discovered, and new drugs are being developed as drugs to treat prostate cancer. Representative candidate compounds that have been studied to be effective in prostate cancer include apigenin, acacetin and tangeretin of the flavone family among flavonoids. In this review, we look at the effects of these three flavones on prostate cancer cells via apoptosis in vitro and in vivo. Furthermore, in addition to the existing drugs, we suggest the three flavones and their effectiveness as natural anticancer agents, a treatment model for prostate cancer. © 2023 by the authors.

키워드

apoptosiscancer cell deathflavonesflavonoidsprostate cancerANDROGEN DEPRIVATION THERAPYMESENCHYMAL TRANSITIONIN-VITRORISKPROGRESSIONRECEPTORAPIGENINMECHANISMSCLASSIFICATIONANTIANDROGEN
제목
Flavones: The Apoptosis in Prostate Cancer of Three Flavones Selected as Therapeutic Candidate Models
저자
Jeong, Se HyoKim, Hun HwanPark, Min YoungBhosale, Pritam BhagwanAbusaliya, AbuyaseerWon, Chung KilPark, Kwang IlKim, EunhyeHeo, Jeong DooKim, Hyun WookAhn, MeejungSeong, Je KyungKim, Gon Sup
DOI
10.3390/ijms24119240
발행일
2023-05
유형
Review
저널명
International Journal of Molecular Sciences
24
11