Myoprotective effect of mangosteen (Garcinia mangostana L.) pericarp methanol extract

초록

Skeletal muscle atrophy is characterized by the loss of muscle mass and function. Dexamethasone, a widely used anti-inflammatory agent, can induce skeletal muscle atrophy and is commonly used in experimental muscle atrophy models. This study investigated the protective effects of methanol extracts from mangosteen (Garcinia mangostana L.) pericarp against dexamethasone-induced muscle atrophy in C2C12 cells. Mangosteen pericarp extract restored myotube diameter and suppressed MuRF1 and Atrogin-1 expression. HPLC analysis identified α-mangostin as the major compound in the extract, suggesting its potential as a natural therapeutic candidate for muscle atrophy.

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