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포도당으로 유도된 in vitro 뇌신경세포 독성에 대한다래 순 아세트산에틸 분획물의 보호 효과
- Yoo, S.K.;
- Park, S.K.;
- Kim, J.M.;
- Kang, J.Y.;
- Park, S.B.;
- ... Heo, H.J.;
- 외 3명
SCOPUS
1초록
The current study investigated in vitro anti-diabetic and neuroprotective effects of the ethyl acetate fraction in Actinidia arguta sprouts (EFAS), on H 2 O 2 and high glucose-induced cytotoxicity in human neuroblastoma MC-IXC cells. EFAS had high total phenolic and total flavonoid contents. An assessment of 2,2'-azino-bis (3-ethylbenzothiazoline-6-sulfonic acid) radical scavenging activity of EFAS, as well as its potential for inhibiting malondialdehyde production, indicated that EFAS may possess significant antioxidant properties. EFAS exerted inhibitory effects on α-glucosidase via glycemic regulation which forms advanced glycation end products. In addition, EFAS exhibited significant acetylcholinesterase inhibitory effects. Moreover, EFAS displayed protective effects against H 2 O 2 and high glucose-induced cell death, and inhibited the generation of reactive oxygen species in MC-IXC cells. Finally, the main physiological compound of EFAS was identified via high performance liquid chromatography as a rutin. ?The Korean Society of Food Science and Technology
키워드
- 제목
- 포도당으로 유도된 in vitro 뇌신경세포 독성에 대한다래 순 아세트산에틸 분획물의 보호 효과
- 제목 (타언어)
- Protective effect of ethyl acetate fraction from Actinidia arguta sprout against high glucose-induced in vitro neurotoxicity
- 저자
- Yoo, S.K.; Park, S.K.; Kim, J.M.; Kang, J.Y.; Park, S.B.; Han, H.J.; Kim, C.-W.; Lee, U.; Heo, H.J.
- 발행일
- 2018-10
- 유형
- Article
- 저널명
- 한국식품과학회지
- 권
- 50
- 호
- 5
- 페이지
- 517 ~ 527
- 언어
- KOR
- 출판사
- Korean Society of Food Science and Technology
- 발행국가
- 대한민국
- 분량
- 11 페이지
- ISSN
- P 0367-6293