Prognostic Role of S100A8 and S100A9 Protein Expressions in Non-small Cell Carcinoma of the Lungopen access
- Koh, Hyun Min; An, Hyo Jung; Ko, Gyung Hyuck; Lee, Jeong Hee; Lee, Jong Sil; Kim, Dong Chul; Yang, Jung Wook; Kim, Min Hye; Kim, Sung Hwan; Jeon, Kyung Nyeo; Lee, Gyeong-Won; Jang, Se Min; Song, Dae Hyun
- Issue Date
- KOREAN SOC PATHOLOGISTS
- S100A8; S100A9; Carcinoma; non-small cell lung; Prognosis
- JOURNAL OF PATHOLOGY AND TRANSLATIONAL MEDICINE, v.53, no.1, pp.13 - 22
- Journal Title
- JOURNAL OF PATHOLOGY AND TRANSLATIONAL MEDICINE
- Start Page
- End Page
- Background: S100A8 and S100A9 have been gaining recognition for modulating tumor growth and metastasis. This study aimed at evaluating the clinical significance of S100A8 and S100A9 in non-small cell lung cancer (NSCLC). Methods: We analyzed the relationship between S100A8 and S100A9 expressions, clinicopathological characteristics, and prognostic significance in tumor cells and peritumoral inflammatory cells. Results: The positive staining of S100A8 in tumor cells was significantly increased in male (p<.001), smoker (p= .034), surgical method other than lobectomy (p=.024), squamous cell carcinoma (SQCC) (p< .001) and higher TNM stage (p=.022) compared with female, non-smoker, lobectomy, adenocarcinoma (ADC), and lower stage. The proportion of tumor cells stained for S100A8 was related to histologic type (p<.001) and patient sex (p= .027). The proportion of inflammatory cells stained for S100A8 was correlated with patient age (p=.022), whereas the proportion of inflammatory cells stained for S100A9 was correlated with patient sex (p<.001) and smoking history (p=.031). Moreover, positive staining in tumor cells, more than 50% of the tumor cells stained and less than 30% of the inflammatory cells stained for S100A8 and S100A9 suggested a tendency towards increased survivability in SQCC but towards decreased survivability in ADC. Conclusions: S100A8 and S100A9 expressions right be potential prognostic markers in patients with NSCLC.
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- College of Medicine > Department of Medicine > Journal Articles
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