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Bacterial neuraminidase inhibition by phenolic compounds from Usnea longissimaopen access

Authors
Ullah, M.Uddin, Z.Song, Y. H.Li, Z. P.Kim, J. Y.Ban, Y. J.Park, K. H.
Issue Date
Jan-2019
Publisher
ELSEVIER
Keywords
Usnea longissima; Lichen metabolites; Structural characterization; Bacterial neuraminidase; Enzyme kinetics
Citation
SOUTH AFRICAN JOURNAL OF BOTANY, v.120, pp.326 - 330
Indexed
SCIE
SCOPUS
Journal Title
SOUTH AFRICAN JOURNAL OF BOTANY
Volume
120
Start Page
326
End Page
330
URI
https://scholarworks.bwise.kr/gnu/handle/sw.gnu/9580
DOI
10.1016/j.sajb.2018.10.020
ISSN
0254-6299
Abstract
Activity-guided phytochemical investigation of the methanol extract of Usnea longissima led to the isolation of nine (1-9) phenolic metabolites, including compounds 6 and 7, which were reported for the first time from this species. All isolated compounds were completely characterized through spectroscopic analysis, including 2D NMR and HREIMS data. Individually, the activity of each purified compound was assessed against bacterial neuraminidase (BNA), and most of them displayed dose-dependent inhibition. Among the purified compounds, compounds 2 and 3 exhibited significant inhibitory activities, with IC50 values of 7.8 and 8.2 mu M, respectively, and had three-fold greater potency than the reference compound quercetin (IC50=21.4 mu M). Furthermore, enzyme kinetics revealed that compounds 2 and 3 exhibited reversible and mixed type-I inhibitory behaviors, with inhibitory constant (K-i) values of 6.8 and 7.2 mu M, respectively. Our results revealed the potential of U. longissima in inhibiting the enzyme BNA and highlighted its additional medicinal properties. (c) 2018 SAAB. Published by Elsevier B.V. All rights reserved.
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Park, Ki Hun
대학원 (응용생명과학부)
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