Labdane-type Diterpenes from Pinus eldarica Needles and Their Anti-Helicobacter pylori Activityopen access
- Jeong, Se Yun; Na, Myung Woo; Park, Eon Chung; Kim, Jin-Chul; Kang, Dong-Min; Hamishehkar, Hamed; Ahn, Mi-Jeong; Kim, Jung Kyu; Kim, Ki Hyun
- Issue Date
- AMER CHEMICAL SOC
- ACS OMEGA, v.7, no.33, pp.29502 - 29507
- Journal Title
- ACS OMEGA
- Start Page
- End Page
- Pinus eldarica is a medicinal tree used in traditional herbal medicine for the treatment of bronchial asthma and various skin diseases. As part of our ongoing search for bioactive phytochemicals with novel structures in natural products, we performed a phytochemical analysis of the methanol (MeOH) extract from P. eldarica needles collected in Iran. Phytochemical investigation of the MeOH extract, aided by liquid chromatography-mass spectrometry-based analysis, resulted in the isolation and identification of three labdane-type diterpenes (1-3), including a new and relatively unique norlabdane-type diterpene with a peroxide moiety, eldaricoxide A (1). The chemical structures of the isolated labdane-type diterpenes were elucidated by analyzing the spectroscopic data from 1D and 2D NMR and high-resolution electrospray ionization-mass spectrometry. The absolute configuration of eldaricoxide A (1) was established by employing a computational method, including electronic circular dichroism calculation and specific optical rotation. An anti-Helicobacter pylori test was conducted, where compound 3 exhibited the most potent antibacterial activity against H. pylori strain 51, inducing 72.7% inhibition (MIC50 value of 92 mu M), whereas eldaricoxide A (1) exhibited moderate antibacterial activity against H. pylori strain 51, inducing 54.5% inhibition (MIC50 value of 95 mu M). These findings demonstrated that the identified bioactive labdane-type diterpenes 1 and 3 can be applied in the development of novel antibiotics against H. pylori for the treatment of gastric and duodenal ulcers.
- Files in This Item
- There are no files associated with this item.
- Appears in
- 약학대학 > 약학과 > Journal Articles
Items in ScholarWorks are protected by copyright, with all rights reserved, unless otherwise indicated.