Drug resistance in extra-pulmonary tuberculosis in South Korea: comparison with pulmonary tuberculosis
- Mok, J.; Kang, B. H.; Kim, H-J.; Lee, S. J.; Lee, T.; Lee, H-K.; Cho, Y. J.; Jeon, D.
- Issue Date
- INT UNION AGAINST TUBERCULOSIS LUNG DISEASE (I U A T L D)
- EPTB; TB; pulmonary; resistance; South Korea
- INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE, v.23, no.2, pp.151 - +
- Journal Title
- INTERNATIONAL JOURNAL OF TUBERCULOSIS AND LUNG DISEASE
- Start Page
- End Page
- OBJECTIVE: To compare the prevalence of and trends in drug resistance in extra-pulmonary tuberculosis (EPTB) and pulmonary tuberculosis (PTB). METHODS: We retrospectively analysed the results of phenotypic drug susceptibility testing (DST) in culture-confirmed TB patients from January 2010 to December 2014 at seven university hospitals in South Korea. RESULTS: Of 5599 patients included, 320 (5.7%) were classified in the EPTB group and 5279 (94.3%) in the PTB group. The proportion of EPTB among all TB cases had gradually increased from 2010 to 2014 (P = 0.004). Among both new and previously treated patients, there were no significant differences in rates of resistance to any kind of anti-tuberculosis drug between the EPTB and PTB groups. The trends in drug resistance rates among new patients were similar in both the EPTB and PTB groups. The rates of multidrug-resistant TB among new patients gradually decreased in both groups (P = 0.031 and P = 0.001, respectively). CONCLUSION: The prevalence of and trends in drug resistance among new patients are not significantly different between patients with EPTB and those with PTB.
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- College of Medicine > Department of Medicine > Journal Articles
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