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RAB27A is an independent prognostic factor in clear cell renal cell carcinoma
- Authors
- An, Hyo Jung; Song, Dae Hyun; Koh, Hyun Min; Ko, Gyung Hyuck; Lee, Jeong-Hee; Kim, Dong Chul; Yang, Jung Wook; Kim, Min Hye; Seo, Deok Ha; Jang, Se Min; Lee, Jong Sil
- Issue Date
- Mar-2019
- Publisher
- FUTURE MEDICINE LTD
- Keywords
- clear cell; intensity; metastasis; nuclear grade; progression; RAB27A; RAB27B; renal cell carcinoma; T stage; tumor
- Citation
- BIOMARKERS IN MEDICINE, v.13, no.4, pp 239 - 247
- Pages
- 9
- Indexed
- SCIE
SCOPUS
- Journal Title
- BIOMARKERS IN MEDICINE
- Volume
- 13
- Number
- 4
- Start Page
- 239
- End Page
- 247
- ISSN
- 1752-0363
1752-0371
- Abstract
- Aim: To examine the expression of RAB27A and RAB27B in clear cell renal cell carcinoma (CCRCC). Materials & methods: The intensity and proportion of tumor cells staining positive for RAB27A and RAB27B in a total of 304 cores were evaluated. Results: The T stage showed a significant correlation with RAB27A intensity (p < 0.001). In multivariate analysis, CCRCC with negative intensity of RAB27A expression demonstrated poor disease-specific survival (hazard ratio: 6.821, 95% CI: 1.128-41.241; p-value = 0.036). Conclusion: RAB27A is an independent prognostic factor in CCRCC.
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