Parvovirus B19 infection presenting with neutropenia and thrombocytopenia Three case reportsopen access
- Shin, Hyoshim; Park, Sungwoo; Lee, Gyeong-Won; Koh, Eun-Ha; Kim, Hyun-Young
- Issue Date
- LIPPINCOTT WILLIAMS & WILKINS
- neutropenia; parvovirus B19; pure red cell aplasia; thrombocytopenia
- MEDICINE, v.98, no.35
- Journal Title
- Rationale: Parvovirus B19 (PV) infection is usually symptomless and can cause benign, short-lived conditions. Anemia associated with PRCA is the most representative hematologic manifestation, but neutropenia and thrombocytopenia have been rarely reported. Patient concerns: Three patients were admitted to the hospital with neutropenia and thrombocytopenia. The accompanying symptoms were fever, myalgia, rash, or arthralgia, and all patients were previously healthy. Diagnosis: Patients were positive for PV PCR and diagnosed with PV infection. Before the diagnosis of PV infection, 2 patients underwent BM study and almost absence of erythroid progenitor cells in BM aspiration were a clue for the PV infection. Other BM findings were hypocellular marrow and a few hemophagocytic histiocytes. Interventions: Patients received supportive care with follow-up of CBC. Outcomes: All 3 patients spontaneously recovered from neutropenia and thrombocytopenia within 3 weeks without severe complications. Lessons: The evaluation of PV infection should be considered in situations where there is neutropenia and thrombocytopenia in healthy individuals even without anemia as a differential diagnosis.
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- College of Medicine > Department of Medicine > Journal Articles
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